Free Shipping on U.S. Orders Over $35 100% Satisfaction Guarantee

MPO

muscle performance optimizer

MPO

muscle performance optimizer

Athleticism, power, strength, speed, endurance, and recovery are the result of 1000’s of chemical reactions in the muscles and nerves. MPO works at the biochemical level to increase force production, power, and endurance, and to help you rebuild post-exercise. Each time you take MPO, you’ll see noticeable improvements in game performance and training.*

When every second and every inch is the difference between winning and losing, take MPO.

  • Take prior to training & competition to maximize athletic performance.*
  • Take daily for improved muscle growth and recovery.*
  • Ideal for athletes across all spectrums:
    • Power: Olympic and Powerlifting
    • Speed & Power: Football, Rugby, MMA, Hockey, WODs
    • Speed & Endurance: Soccer, Tennis, Lacrosse, Swimming
    • Endurance: Running, Biking, Swimming

free shipping & 100% satisfaction guarantee

is mpo right for me?

Athleticism is defined by Webster as the combination of qualities that are characteristic of an athlete. In our opinion, these physical qualities include strength, power, aerobic & anaerobic endurance, your ability to recover, and flexibility. Other than the last one, MPO will improve every characteristic of your physical athletic ability.*

studied in pro athletes

Here’s some data: In a study of professional and D1 hockey players during a 13 week summer combine, athletes using MPO demonstrated an 11-18% increase in average power production, up to an 18.9% increase in peak power, and a 4.5% increase in anaerobic endurance. As is typically seen during intense combine training, the athletes not using MPO saw either no improvement, or declines in these metrics.

for pure strength

MPO increases the amount of ATP (fuel) in the muscle, decreases the accumulation of lactic acid, and inhibits neural fatigue. MPO also has multiple mTOR, IGF-1, GH, and satellite cell stimulators that increase muscle growth, as well as improve repair and recovery. These factors combine to improve your strength, to allow you to increase your set weight, reps, and time under tension, and to shorten your rest phase. You can expect to set new PR’s more frequently, and if you use MPO daily with proper nutrition, you can expect greater increases in muscle mass than you would without MPO.

when peak power meets speed

High intensity sports call for explosive bouts of maximal power, sustained focus, and all out speed. Football, rugby, sprinting, metabolic conditioning, WOD’s, and MMA all come to mind. Athletes in these areas of expertise require repetitive power and speed movements used with skill and accuracy. MPO increases your power production, maintains your speed and agility, and provides resistance to fatigue. This ensures peak performance and focus from start to finish.

speed, endurance, & consistency

Some sports, such as basketball, soccer, hockey, tennis, and lacrosse call for the unique combination of speed and endurance; of fast twitch and slow twitch muscle fibers. Athletes in these sports will see improvements in both physical qualities while using MPO. Since MPO inhibits muscle breakdown, neural fatigue, and the buildup of lactic acid, athletes will also experience quicker recovery between sprints, and sustained mental focus. Impressively, athletes will also maintain weight and avoid being worn down over the course of a long season while regularly using MPO. This equals greater consistency day in and day out, which is key to athletic success.

going the distance

For some, a finely tuned cardiovascular system, aerobic muscle fibers, and a strong mind are the tools of the trade. Long distance runners, cyclists, swimmers, hikers, and climbers fit into this category. MPO works unlike any other supplement for these endurance athletes. It increases VO2 max. It increases muscle ATP (the fuel needed for muscles to fire consistently during long athletic events). It also inhibits lactic acid build up. Higher lactic acid levels prevent glucose from being converted into ATP. Further, MPO prevents fatigue in the neuromuscular and central nervous systems. With less fatigue, your mind can stay sharp and focused. Lastly, it decreases muscle breakdown for improved recovery.

recovery is paramount

For all athletes, recovery is the key to success and consistency. MPO decreases muscle breakdown resulting from the micro-injuries that occur with exercise. This enables athletes to recover faster and minimizes DOMS (delayed onset muscle soreness), enabling you to maintain more muscle, repair muscle faster, and perform better day to day following intense athletic work. Often, it is not that exercise that is indicative of consistency and improved future performance, but the physiologic changes that happen during the recovery phase.

A Word From The Doctor

Why did you formulate this?

“The studies say it all. The right supplements at the right dose will produce measurable benefits that you can’t get from food alone. With that said, I never saw a measurable difference in my training, or my son’s training from anything on the market. The products were underdosed, were missing key ingredients, or had misleading labels. So, I took 5 proven nutraceuticals at clinical doses and combined them to create our flagship product MPO. The results exceeded expectations, and the synergy of the ingredients became greater than the results of the individual parts. MPO has enabled me to set multiple PR’s in my late 50’s, and produces quantifiable results in all the professional athletes we work with.”

HMB

3000mg

HMB is a naturally occurring substance and a metabolite of leucine. Some of the leucine that comes in through your daily diet is ultimately converted by the body into HMB. This amount however, is quite minuscule. As such, we need to supplement with HMB to realize its full potential.

The main benefits of HMB are promoting muscle growth and muscle strength, and preventing muscle breakdown.

To add size and strength, HMB stimulates muscle protein synthesis, the main mechanism that causes your muscles to grow. The higher your levels of MPS, the greater your muscle-building potential. Specifically, HMB has been shown to increase MPS through the activation of the mTOR signaling pathway, which helps coordinate the delivery of fresh nutrients like amino acids and oxygen to your muscles.

To highlight its effectiveness, one study compared the effects of HMB to placebo. After 12 weeks of supplementation, researchers found significantly greater increases in lean muscle mass in participants who ingested HMB vs placebo (7.4 kg vs 2.1 kg respectively). The participants consuming HMB also added 55 more kgs to their squat, bench, and deadlift totals in comparison to subjects who received only a placebo.

To prevent muscle breakdown, HMB prevents the process known as muscle protein breakdown (MPB). In simple terms, less MPB ultimately equates to less recovery time. If an intense workout doesn’t do as much damage to your muscle tissues, it won’t take your body as much time to make repairs. Specifically, HMB alters muscle metabolism, and is shown to decrease the body’s production of enzymes like lactate dehydrogenase, which play a primary role in triggering MPB.

Phosphatidic Acid (PA) (Mediator™ PA)

750mg

Phosphatidic acid (PA) is a biomolecule produced naturally within your body. It plays an important part in cell signaling, the process of communication that takes place between your body’s cells in order to coordinate and regulate their actions.

Specifically, phosphatidic acid helps to promote mTOR signaling, which once activated, helps promote muscle protein synthesis and cellular growth. The mTOR signaling pathway actively senses and reacts to environmental stimuli, helping to coordinate the transportation of proteins (along with oxygen and other biochemicals) to muscle cells in need of repair.

To date, most studies have found that compared to resistance training alone, PA supplementation led to significantly greater gains in size and strength.

Over the course of one 8-week resistance training study, participants given phosphatidic acid gained on average 2.4 more kilograms of lean body mass than those given placebo. In another 8-week trial, those given phosphatidic acid added on average almost 20 more kilograms to their 1 rep max on the leg press than those given placebo, +52kg vs +32.5kg respectively.

Beta-Alanine

2000mg

Beta-alanine is a naturally occurring non-essential amino acid that produces carnosine, a peptide that acts as an inhibitor to the chemical reactions that occur in your muscles during physically demanding exercise.

As such, the main benefits of beta-alanine are its ability to increase anaerobic endurance, and to help build strength.

When you work out, your muscles are actively taking in glucose, which is your body’s primary fuel source. When glucose is burnt up, it leaves behind lactic acid. As the acidity builds up in your muscles, their capacity to take in more glucose becomes diminished. Without the glucose needed for energy, your muscles become exhausted. That… and you “feel the burn”.

The carnosine that beta-alanine creates though, helps to reduce the buildup of lactic acid, which allows additional glucose to enter into your muscles during high-intensity exercise. In clinical trials, sprinters who consumed beta-alanine were able to sustain greater power outputs for longer durations of time compared to sprinters who did not.

While beta-alanine is most effective for high-intensity exercise, that doesn’t mean that it has no benefit for endurance athletes. In fact, in one study involving elite cyclists, researchers found that supplementing with beta-alanine significantly improves cyclists’ sprinting performances at the end of long bouts of endurance-based exercise.

Finally, studies also show that beta-alanine increases strength. In one such study, researchers found that after 5 weeks of training, those who supplemented with beta-alanine saw significantly greater increases in their power outputs compared to the placebo group.

HICA

1500mg

HICA is another naturally occurring, bioactive, organic compound found in the body that, when provided as a supplement, significantly enhances muscular function and development.

Like HMB, your body naturally produces HICA during the metabolism of leucine. With that said, the muscles and connective tissues use and metabolize leucine via two different biochemical pathways, and of course HMB uses one, and HICA uses the other (the KIC pathway to be specific).

Also like HMB, scientists consider HICA to be anabolic since it enhances muscle protein synthesis. It may do this via a variety of means, but studies indicate that HICA is anabolic because it supports mTOR activation.

HICA has also been shown to have anti-catabolic properties as well, meaning that it helps to prevent the breakdown of muscle proteins found within muscle tissues. As you exercise intensely, your muscles undergo micro-trauma that causes the muscle cells to break down. We all feel the effects of this micro-trauma 24-48 hours after intense exercise in the form of delayed onset muscle soreness (DOMS). HICA significantly decreases this breakdown or catabolism. The result of this is less DOMS, and more lean muscle to build upon.

In recent athlete studies, scientists noted that the athletes who took HICA over a 6-week period gained 2 pounds and noted significantly less muscle soreness. What is even more interesting about the trials though, is that the placebo group actually lost lean muscle mass. This makes HICA a very important supplement for any athlete performing high-intensity exercise.

Creatine Monohydrate

4500mg

Creatine monohydrate is one of the original and most extensively studied weightlifting supplements on the market. In fact, there have been thousands of studies spanning multiple decades that show creatine is a top supplement for improving exercise performance.

Creatine is a naturally occurring compound that’s found primarily in your muscle cells. The main benefits of creatine are increasing muscle energy, muscle size, and muscle strength.

To provide your muscles with energy, creatine increases the amount of phosphocreatine within your muscle cells. Phosphocreatine is used by your muscles during high-intensity activity to produce ATP, which is an energy source, and also the driving factor behind numerous processes within the human body such as muscle contractions.

Impressively, studies consistently demonstrate that creatine monohydrate can increase phosphocreatine concentrations in the muscles by as much as 40%. This means that there is more available energy in your muscles when exercising, which leads to improvements in both anaerobic and aerobic endurance.

To increase muscle growth, creatine increases intramuscular concentrations of IGF, and increases the number of satellite cells and myonuclei in your muscle fibers. Studies show that both of these factors help add lean muscle mass. The combination of these factors, coupled with an increase in available energy, leads to improvements in muscle strength as well.

Amazingly, both short and long-term studies show creatine monohydrate leads to at least 5-15% greater gains in strength and performance. One study even demonstrated an increase in 1RM (one rep max) of 8%, and an increased bench press of 16-43% when compared to placebo.

suggested use

directions

Drink MPO 30 minutes prior to exercise. MPO is not meant to be sipped. Drink completely at one time. To gain muscle we recommend taking MPO daily, even on days off. It is not necessary to cycle on and off MPO.

FAQ's

It is the first of its kind, physician formulated, athletic performance enhancer. Experience real increases in your muscle strength, power, endurance, and recovery.

Though we recommend taking MPO before all workouts and competitions, MPO is not a pre-workout in the traditional sense. MPO does not contain any stimulants like traditional pre-workouts. As such, you will not develop stim fatigue like you do on standard pre-workouts. Instead, MPO actually improves the way your muscles function to improve workouts and athletic performance.

If you are looking to build muscle or prevent muscle loss (such as when you are recovering from injury or because of aging), we recommend taking MPO every day, including days off from exercise.

If you are looking to add stimulants to your pre-workout, then yes, you can stack MPO with a traditional pre-workout.  But a better option would be to use MPO with BRAIN.

Yes it is.

MPO will kick in in 30 minutes.**

If you are using this prior to training, we suggest you take MPO at least 30 minutes before hitting the gym.

If you are using this for athletic competition, most of our professional athletes take MPO 30 minutes before the competition starts.

Yes. MPO is produced in a GMP (Good Manufacturing Practice), state of the art facility to ensure quality and your safety.

Customer Reviews

Based on 103 reviews
87%
(90)
10%
(10)
3%
(3)
0%
(0)
0%
(0)
M
Milissa Resnick
Excellent

This is the real deal! Never felt better!

J
Joe Gillespie
Great Product

My son has been using this for 2 months now, and he won't work out without it. He feels like he gets so much more from his workouts.

T
Tim B
I admit, I'm new to using the brand

I am new to using the brand, I didn't see the uptick in strength I had hoped for. Maybe it was a placebo?

A
Alvin Bartolome
MPO

I noticed some gains in my lift and better muscle definition would try it for a longer use.

R
Robert Sutherland
Glad I gave MPO a Chance

I am 63 years and never was really interested in muscle gain. On July 20, 2020 I began my muscle growth journey. Initially, all I did was pushups: 10 sets of 30 on my best day, no less than 180 pushups per day. A friend at work built us a little outdoor gym, with dumbells, pull-up bar, dips station, plus a double-ended speed bag. About that time, I discovered Dioxyme and bough the powdered why protein, also MPO. I read what Dioxyme had to say about what I could expect from MPO: increased reps, muscle repair, better recovery. It's all true. I work out pretty hard and do lots of sets. I am able to go on a long time, and I have almost no muscle pain. I am about to celebrate my 13-month anniversary and I am getting big! The younger guys at work step out of my way, and many have said "I've got to get back to the gym - you're making me look bad." And the women are definitely taking a closer look! MPO and Ultra Whey Protein are the real deal. So glad I found Dioxyme.

references

1. Holeček M. Beta-hydroxy-beta-methylbutyrate supplementation and skeletal muscle in healthy and muscle-wasting conditions. J Cachexia Sarcopenia Muscle. 2017 Aug;8(4):529-541. doi: 10.1002/jcsm.12208. Epub 2017 May 10. PMID: 28493406; PMCID: PMC5566641.

2. Zanchi NE, Gerlinger-Romero F, Guimarães-Ferreira L, de Siqueira Filho MA, Felitti V, Lira FS, Seelaender M, Lancha AH Jr. HMB supplementation: clinical and athletic performance-related effects and mechanisms of action. Amino Acids. 2011 Apr;40(4):1015-25. doi: 10.1007/s00726-010-0678-0. Epub 2010 Jul 6. PMID: 20607321.

3. Eley HL, Russell ST, Baxter JH, Mukerji P, Tisdale MJ. Signaling pathways initiated by beta-hydroxy-beta-methylbutyrate to attenuate the depression of protein synthesis in skeletal muscle in response to cachectic stimuli. Am J Physiol Endocrinol Metab. 2007 Oct;293(4):E923-31. doi: 10.1152/ajpendo.00314.2007. Epub 2007 Jul 3. PMID: 17609254.

4. Aversa Z, Bonetto A, Costelli P, Minero VG, Penna F, Baccino FM, Lucia S, Rossi Fanelli F, Muscaritoli M. β-hydroxy-β-methylbutyrate (HMB) attenuates muscle and body weight loss in experimental cancer cachexia. Int J Oncol. 2011 Mar;38(3):713-20. doi: 10.3892/ijo.2010.885. Epub 2010 Dec 23. PMID: 21184031.

5. Panton LB, Rathmacher JA, Baier S, Nissen S. Nutritional supplementation of the leucine metabolite beta-hydroxy-beta-methylbutyrate (hmb) during resistance training. Nutrition. 2000 Sep;16(9):734-9. doi: 10.1016/s0899-9007(00)00376-2. PMID: 10978853.

6. Malafarina V, Uriz-Otano F, Malafarina C, Martinez JA, Zulet MA. Effectiveness of nutritional supplementation on sarcopenia and recovery in hip fracture patients. A multi-centre randomized trial. Maturitas. 2017 Jul;101:42-50. doi: 10.1016/j.maturitas.2017.04.010. Epub 2017 Apr 22. PMID: 28539168.

7. Wilson JM, Fitschen PJ, Campbell B, Wilson GJ, Zanchi N, Taylor L, Wilborn C, Kalman DS, Stout JR, Hoffman JR, Ziegenfuss TN, Lopez HL, Kreider RB, Smith-Ryan AE, Antonio J. International Society of Sports Nutrition Position Stand: beta-hydroxy-beta-methylbutyrate (HMB). J Int Soc Sports Nutr. 2013 Feb 2;10(1):6. doi: 10.1186/1550-2783-10-6. PMID: 23374455; PMCID: PMC3568064.

8. Wilson JM, Lowery RP, Joy JM, Andersen JC, Wilson SM, Stout JR, Duncan N, Fuller JC, Baier SM, Naimo MA, Rathmacher J. The effects of 12 weeks of beta-hydroxy-beta-methylbutyrate free acid supplementation on muscle mass, strength, and power in resistance-trained individuals: a randomized, double-blind, placebo-controlled study. Eur J Appl Physiol. 2014 Jun;114(6):1217-27. doi: 10.1007/s00421-014-2854-5. Epub 2014 Mar 6. PMID: 24599749; PMCID: PMC4019830.

9. Wilkinson DJ, Hossain T, Hill DS, Phillips BE, Crossland H, Williams J, Loughna P, Churchward-Venne TA, Breen L, Phillips SM, Etheridge T, Rathmacher JA, Smith K, Szewczyk NJ, Atherton PJ. Effects of leucine and its metabolite β-hydroxy-β-methylbutyrate on human skeletal muscle protein metabolism. J Physiol. 2013 Jun 1;591(11):2911-23. doi: 10.1113/jphysiol.2013.253203. Epub 2013 Apr 3. PMID: 23551944; PMCID: PMC3690694.

10. Nissen S, Sharp R, Ray M, Rathmacher JA, Rice D, Fuller JC Jr, Connelly AS, Abumrad N. Effect of leucine metabolite beta-hydroxy-beta-methylbutyrate on muscle metabolism during resistance-exercise training. J Appl Physiol (1985). 1996 Nov;81(5):2095-104. doi: 10.1152/jappl.1996.81.5.2095. PMID: 8941534.

11. Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell. 2012 Apr 13;149(2):274-93. doi: 10.1016/j.cell.2012.03.017. PMID: 22500797; PMCID: PMC3331679.

12. O'Neil TK, Duffy LR, Frey JW, Hornberger TA. The role of phosphoinositide 3-kinase and phosphatidic acid in the regulation of mammalian target of rapamycin following eccentric contractions. J Physiol. 2009 Jul 15;587(Pt 14):3691-701. doi: 10.1113/jphysiol.2009.173609. Epub 2009 May 26. PMID: 19470781; PMCID: PMC2742291.

13. Shad BJ, Smeuninx B, Atherton PJ, Breen L. The mechanistic and ergogenic effects of phosphatidic acid in skeletal muscle. Appl Physiol Nutr Metab. 2015 Dec;40(12):1233-41. doi: 10.1139/apnm-2015-0350. Epub 2015 Sep 21. PMID: 26566242.

14. Joy, J.M., Lowery, R.P., Dudeck, J.E. et al. Phosphatidic acid supplementation increases skeletal muscle hypertrophy and strength. J Int Soc Sports Nutr 10, P13 (2013). https://doi.org/10.1186/1550-2783-10-S1-P13

15. Escalante G, Alencar M, Haddock B, Harvey P. The effects of phosphatidic acid supplementation on strength, body composition, muscular endurance, power, agility, and vertical jump in resistance trained men. J Int Soc Sports Nutr. 2016 Jun 2;13:24. doi: 10.1186/s12970-016-0135-x. PMID: 27274715; PMCID: PMC4891923.

16. Joy JM, Gundermann DM, Lowery RP, Jäger R, McCleary SA, Purpura M, Roberts MD, Wilson SM, Hornberger TA, Wilson JM. Phosphatidic acid enhances mTOR signaling and resistance exercise induced hypertrophy. Nutr Metab (Lond). 2014 Jun 16;11:29. doi: 10.1186/1743-7075-11-29. PMID: 24959196; PMCID: PMC4066292.

17. Artioli GG, Gualano B, Smith A, Stout J, Lancha AH Jr. Role of beta-alanine supplementation on muscle carnosine and exercise performance. Med Sci Sports Exerc. 2010 Jun;42(6):1162-73. doi: 10.1249/MSS.0b013e3181c74e38. PMID: 20479615.

18. Bishop D, Edge J, Goodman C. Muscle buffer capacity and aerobic fitness are associated with repeated-sprint ability in women. Eur J Appl Physiol. 2004 Aug;92(4-5):540-7. doi: 10.1007/s00421-004-1150-1. PMID: 15168128.

19. Culbertson JY, Kreider RB, Greenwood M, Cooke M. Effects of beta-alanine on muscle carnosine and exercise performance: a review of the current literature. Nutrients. 2010 Jan;2(1):75-98. doi: 10.3390/nu2010075. Epub 2010 Jan 25. PMID: 22253993; PMCID: PMC3257613.

20. Trexler ET, Smith-Ryan AE, Stout JR, Hoffman JR, Wilborn CD, Sale C, Kreider RB, Jäger R, Earnest CP, Bannock L, Campbell B, Kalman D, Ziegenfuss TN, Antonio J. International society of sports nutrition position stand: Beta-Alanine. J Int Soc Sports Nutr. 2015 Jul 15;12:30. doi: 10.1186/s12970-015-0090-y. PMID: 26175657; PMCID: PMC4501114.

21. Sale C, Saunders B, Harris RC. Effect of beta-alanine supplementation on muscle carnosine concentrations and exercise performance. Amino Acids. 2010 Jul;39(2):321-33. doi: 10.1007/s00726-009-0443-4. Epub 2009 Dec 20. PMID: 20091069.

22. Blancquaert L, Everaert I, Derave W. Beta-alanine supplementation, muscle carnosine and exercise performance. Curr Opin Clin Nutr Metab Care. 2015 Jan;18(1):63-70. doi: 10.1097/MCO.0000000000000127. PMID: 25474013.

23. Derave W, Ozdemir MS, Harris RC, Pottier A, Reyngoudt H, Koppo K, Wise JA, Achten E. beta-Alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprinters. J Appl Physiol (1985). 2007 Nov;103(5):1736-43. doi: 10.1152/japplphysiol.00397.2007. Epub 2007 Aug 9. PMID: 17690198.

24. Hill CA, Harris RC, Kim HJ, Harris BD, Sale C, Boobis LH, Kim CK, Wise JA. Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity. Amino Acids. 2007 Feb;32(2):225-33. doi: 10.1007/s00726-006-0364-4. Epub 2006 Jul 28. PMID: 16868650.

25. Van Thienen R, Van Proeyen K, Vanden Eynde B, Puype J, Lefere T, Hespel P. Beta-alanine improves sprint performance in endurance cycling. Med Sci Sports Exerc. 2009 Apr;41(4):898-903. doi: 10.1249/MSS.0b013e31818db708. PMID: 19276843.

26. Maté-Muñoz JL, Lougedo JH, Garnacho-Castaño MV, Veiga-Herreros P, Lozano-Estevan MDC, García-Fernández P, de Jesús F, Guodemar-Pérez J, San Juan AF, Domínguez R. Effects of β-alanine supplementation during a 5-week strength training program: a randomized, controlled study. J Int Soc Sports Nutr. 2018 Apr 25;15:19. doi: 10.1186/s12970-018-0224-0. PMID: 29713250; PMCID: PMC5918575.

27. Lang CH, Pruznak A, Navaratnarajah M, Rankine KA, Deiter G, Magne H, Offord EA, Breuillé D. Chronic α-hydroxyisocaproic acid treatment improves muscle recovery after immobilization-induced atrophy. Am J Physiol Endocrinol Metab. 2013 Aug 1;305(3):E416-28. doi: 10.1152/ajpendo.00618.2012. Epub 2013 Jun 11. PMID: 23757407.

28. Barlas P, Craig JA, Robinson J, Walsh DM, Baxter GD, Allen JM. Managing delayed-onset muscle soreness: lack of effect of selected oral systemic analgesics. Arch Phys Med Rehabil. 2000 Jul;81(7):966-72. doi: 10.1053/apmr.2000.6277. PMID: 10896014.

29. Lieber RL, Friden J. Morphologic and mechanical basis of delayed-onset muscle soreness. J Am Acad Orthop Surg. 2002 Jan-Feb;10(1):67-73. PMID: 11809052.

30. Mero AA, Ojala T, Hulmi JJ, Puurtinen R, Karila TA, Seppälä T. Effects of alfa-hydroxy-isocaproic acid on body composition, DOMS and performance in athletes. J Int Soc Sports Nutr. 2010 Jan 5;7:1. doi: 10.1186/1550-2783-7-1. PMID: 20051111; PMCID: PMC2818616.

31. Kreider RB, Kalman DS, Antonio J, Ziegenfuss TN, Wildman R, Collins R, Candow DG, Kleiner SM, Almada AL, Lopez HL. International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. J Int Soc Sports Nutr. 2017 Jun 13;14:18. doi: 10.1186/s12970-017-0173-z. PMID: 28615996; PMCID: PMC5469049.

32. Mero AA, Keskinen KL, Malvela MT, Sallinen JM. Combined creatine and sodium bicarbonate supplementation enhances interval swimming. J Strength Cond Res. 2004 May;18(2):306-10. doi: 10.1519/R-12912.1. PMID: 15142001.

33. Skare OC, Skadberg, Wisnes AR. Creatine supplementation improves sprint performance in male sprinters. Scand J Med Sci Sports. 2001 Apr;11(2):96-102. doi: 10.1034/j.1600-0838.2001.011002096.x. PMID: 11252467.

34. Theodorou AS, Cooke CB, King RF, Hood C, Denison T, Wainwright BG, Havenetidis K. The effect of longer-term creatine supplementation on elite swimming performance after an acute creatine loading. J Sports Sci. 1999 Nov;17(11):853-9. doi: 10.1080/026404199365416. PMID: 10585165.

35. Claudino JG, Mezêncio B, Amaral S, Zanetti V, Benatti F, Roschel H, Gualano B, Amadio AC, Serrão JC. Creatine monohydrate supplementation on lower-limb muscle power in Brazilian elite soccer players. J Int Soc Sports Nutr. 2014 Jun 18;11:32. doi: 10.1186/1550-2783-11-32. PMID: 24991195; PMCID: PMC4077550.

36. Burke DG, Candow DG, Chilibeck PD, MacNeil LG, Roy BD, Tarnopolsky MA, Ziegenfuss T. Effect of creatine supplementation and resistance-exercise training on muscle insulin-like growth factor in young adults. Int J Sport Nutr Exerc Metab. 2008 Aug;18(4):389-98. doi: 10.1123/ijsnem.18.4.389. PMID: 18708688.

37. Deldicque L, Louis M, Theisen D, Nielens H, Dehoux M, Thissen JP, Rennie MJ, Francaux M. Increased IGF mRNA in human skeletal muscle after creatine supplementation. Med Sci Sports Exerc. 2005 May;37(5):731-6. doi: 10.1249/01.mss.0000162690.39830.27. PMID: 15870625.

38. Jówko E, Ostaszewski P, Jank M, Sacharuk J, Zieniewicz A, Wilczak J, Nissen S. Creatine and beta-hydroxy-beta-methylbutyrate (HMB) additively increase lean body mass and muscle strength during a weight-training program. Nutrition. 2001 Jul-Aug;17(7-8):558-66. doi: 10.1016/s0899-9007(01)00540-8. PMID: 11448573.

39. Olsen S, Aagaard P, Kadi F, Tufekovic G, Verney J, Olesen JL, Suetta C, Kjaer M. Creatine supplementation augments the increase in satellite cell and myonuclei number in human skeletal muscle induced by strength training. J Physiol. 2006 Jun 1;573(Pt 2):525-34. doi: 10.1113/jphysiol.2006.107359. Epub 2006 Mar 31. Erratum in: J Physiol. 2006 Sep 15;575(Pt 3):971. PMID: 16581862; PMCID: PMC1779717.

40. Yan Z. Skeletal muscle adaptation and cell cycle regulation. Exerc Sport Sci Rev. 2000 Jan;28(1):24-6. PMID: 11131685.

41. Dangott B, Schultz E, Mozdziak PE. Dietary creatine monohydrate supplementation increases satellite cell mitotic activity during compensatory hypertrophy. Int J Sports Med. 2000 Jan;21(1):13-6. doi: 10.1055/s-2000-8848. PMID: 10683092.

42. Buford TW, Kreider RB, Stout JR, Greenwood M, Campbell B, Spano M, Ziegenfuss T, Lopez H, Landis J, Antonio J. International Society of Sports Nutrition position stand: creatine supplementation and exercise. J Int Soc Sports Nutr. 2007 Aug 30;4:6. doi: 10.1186/1550-2783-4-6. PMID: 17908288; PMCID: PMC2048496.

43. Lanhers C, Pereira B, Naughton G, Trousselard M, Lesage FX, Dutheil F. Creatine Supplementation and Lower Limb Strength Performance: A Systematic Review and Meta-Analyses. Sports Med. 2015 Sep;45(9):1285-1294. doi: 10.1007/s40279-015-0337-4. PMID: 25946994.

44. Lanhers C, Pereira B, Naughton G, Trousselard M, Lesage FX, Dutheil F. Creatine Supplementation and Upper Limb Strength Performance: A Systematic Review and Meta-Analysis. Sports Med. 2017 Jan;47(1):163-173. doi: 10.1007/s40279-016-0571-4. PMID: 27328852.

45. Rawson ES, Volek JS. Effects of creatine supplementation and resistance training on muscle strength and weightlifting performance. J Strength Cond Res. 2003 Nov;17(4):822-31. doi: 10.1519/1533-4287(2003)017<0822:eocsar>2.0.co;2. PMID: 14636102.

46. McMorris T, Mielcarz G, Harris RC, Swain JP, Howard A. Creatine supplementation and cognitive performance in elderly individuals. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2007 Sep;14(5):517-28. doi: 10.1080/13825580600788100. PMID: 17828627.

47. Kreider RB. Effects of creatine supplementation on performance and training adaptations. Mol Cell Biochem. 2003 Feb;244(1-2):89-94. PMID: 12701815.

48. Volek JS, Duncan ND, Mazzetti SA, Staron RS, Putukian M, Gómez AL, Pearson DR, Fink WJ, Kraemer WJ. Performance and muscle fiber adaptations to creatine supplementation and heavy resistance training. Med Sci Sports Exerc. 1999 Aug;31(8):1147-56. doi: 10.1097/00005768-199908000-00011. PMID: 10449017.

* These statements have not been evaluated by the FDA. Our products are not intended to diagnose, treat, cure, or prevent any disease.

** Most users feel a noticeable effect within 30-45 minutes. Results may vary.

Warning Prop 65 for California Residents: This product may expose you to chemicals which are known to the State of California to cause cancer and birth defects or other reproductive harm. For more information, go to https://www.p65warnings.ca.gov/.

Search

Popular search terms: Whey Protein, Creatine, Multivitamin, CLA, TDEE Calculator, Nootropics, Burn Fat, Build Muscle, Energy