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focus · memory · energy


focus · memory · energy

Our natural nootropics improve mental processing, memory, focus, creativity, and athletic performance. We use patented timed-release caffeine to amplify the effect of each ingredient and to provide a smooth, steady delivery of energy for 6 hours with no jitters or crash. Unlock your potential and feel limitless.*

A nootropic formula you can actually feel.

  • you’ll be alert and in-the-zone within 30 minutes**
  • delivers a steady dose of energy every hour for 6 hours
  • the ultimate smart pill to help you work, study, power through your day, tap into your creative side and perform at your best

free shipping & 100% satisfaction guarantee

view comparison chart







stress relief

clinical dose

clinical dose
of alpha gpc

price per

983mg 899mg 666mg 566mg 400mg 400mg $1.73
hvmn sprint 400mg 200g 200g 200g $0.83
MIND LAB PRO universal nootropic 500mg 425mg 450mg 475mg 325mg $2.17
MOON JUICE brain dust n/a n/a n/a n/a n/a n/a $2.68
NEURIVA original 100mg 100mg 100mg $1.10
ONNIT alpha brain n/a n/a n/a n/a n/a n/a $1.77
PREVAGEN regular 10g $1.33
QUALIA mind 1450mg 1050mg 1205mg 850mg 1350mg 750mg $6.32
TRUBRAIN capsules 500mg 350mg 850mg 500mg 1050mg 550mg $4.17
ZHOU neuro-peak 150mg 500mg 250mg 450mg 50mg $0.63

disclaimer. Dioxyme is not affiliated with the brands in this comparison chart.

This formula uses a prop blend and we cannot determine ingredient dosing.

our ingredients

We use trial-proven ingredients at clinically-backed doses that produce measurable results. We never hide behind prop blends or label loopholes.

Alpha GPC Choline


Alpha GPC Choline increases your brain’s ability to focus on the task at hand. It also improves your ability to process information and enables you to remember more.

In fact, studies show that Alpha GPC supplementation is effective in improving tested verbal memory, visual memory, and verbal learning over time.1,2

Interestingly, studies also show it can increase muscular power output by 14%, which is ideal for athletic performance.3

How does this all work?

In your brain, choline is converted into the neurotransmitter acetylcholine, which is critical for brain function and cognition.

Now, with that said, there are 5 different types of choline supplements.

CDP Choline
Alpha GPC Choline

Any guess which one is the best? Alpha GPC Choline, of course.

This is the only form of choline that is not converted into an intermediate before being converted to acetylcholine. As such it is the most potent form available.4,5,6



L-Carnitine is a naturally occurring amino acid with 2 main functions as a nootropic:

helps the brain produce energy 7,8
helps increase the levels of certain neurotransmitters in the brain 7,9

As such, L-carnitine supports improved attention, memory, and learning. It is also neuroprotective.10,11

Interestingly, L-Carnitine and choline work synergistically, and consuming L-Carnitine alongside choline further increases acetylcholine (neurotransmitter) production by 36%.12

L-Carnitine also pairs well with caffeine, as the duo increases endurance through the selective utilization of fats.13


Now, we naturally produce L-Carnitine in our bodies. We also consume it. As a note, it is most commonly found in meat. Unfortunately, though, many of us suffer subclinical deficiencies from inadequate L-Carnitine intake. In fact, 75% of vegetarians and vegans tend to be deficient in L-Carnitine.14,15

For this reason, alongside the numerous aforementioned benefits, L-Carnitine makes for an excellent supplement.



L-Tyrosine is another naturally occurring amino acid. Studies show it will:

improve your mood and help alleviate stress 16
improve your memory 17
improve your performance on complex mental tasks 18
improve your cognitive flexibility 19,20
improve your concentration 21

At this point, I know you’re wondering... how does this all happen?

L-Tyrosine is a precursor for the production of 3 neurotransmitters, and the production of these transmitters leads to the aforementioned benefits.22,23

Additionally, studies show L-Tyrosine supplementation actually prevents the depletion of the neurotransmitters that affect stress, and that modify your stress response.24

Pretty cool, right?

Timed-Release Caffeine


Unbeknownst to most, caffeine is actually the most widely used nootropic in the world. Studies show caffeine will:

increase your reaction time 18,25
increase your alertness 25
improve your memory 26
improve your mood 27

Even more amazing though, caffeine actually amplifies the effectiveness of the other nootropics found in BRAIN.

In our formula, we use patented timed-release caffeine. When taking the recommended dose of 2 capsules, BRAIN provides you with a smooth release of approximately 40 mg of caffeine every hour for 6 hours. For reference, a shot of espresso has just about 60 mg of caffeine.

That may seem like a lot, or that may seem like not enough based on your personal caffeine tolerance. The beauty of BRAIN though, is that you can self-dose based on your preferences.

Moreover, it should be known the timed-release technology eliminates any jitters or crash like those associated with high caffeine energy drinks.



Like some of the others, L-Theanine is a natural amino acid. It is typically found in green tea and black tea.

L-Theanine is pretty amazing with its contrasting dual benefits:

it will improve your mental focus and arousal 28
it will minimize your response to stress 29

Incredibly, when taken by itself, L-Theanine normally creates a relaxed, sleepy state. However, when combined with caffeine, as it is here, it has the opposite effect and actually improves alertness and concentration.30

1-3-7 Trimethylxanthine


1-3-7 Trimethylxanthine is the fancy name for traditional, fast-acting caffeine.

By having traditional caffeine alongside the timed-release caffeine, BRAIN can start working immediately and stay effective for up to 6 hours.

suggested use


Take BRAIN 30 minutes prior to needing energy and focus. A typical serving size is 2 capsules. That said, we recommend taking 1-3 capsules based on your personal caffeine tolerance. Since BRAIN contains extended-release caffeine, we suggest you do not take it within 6 hours of bedtime.

when to take it

study aid: Nootropics are excellent work/study aids that increase focus, memory, and creativity. before exercise: Use BRAIN before workouts or competition to feel in-the-zone. midday slump: Our natural nootropics will push you through your workday by increasing energy and motivation.


Our standard serving size is 2 capsules. 2 capsules will provide you with approximately 40 mg of caffeine every hour for 6 hours. For reference, 60 mg of caffeine is the equivalent of 1 shot of espresso.

Based on your caffeine tolerance, people normally take anywhere from 1-3 capsules.

The patented extended-release technology microencapsulates the caffeine molecules. When the caffeine is consumed, the microencapsulation around the molecules dissolves in your system at different rates.

Yes. You can take this on an empty stomach or with food.

Yes! You can certainly stack Brain with other products based on your personal goals.

Yes. Brain is produced in a GMP (Good Manufacturing Practice), state of the art facility to ensure quality and your safety.

Moreover, the facility manufacturing Brain is independently inspected and registered GMP by NSF International. This means the facility has agreed to follow the strictest standards in the manufacturing business.

Customer Reviews

Based on 109 reviews
Anthony Caterson

Hello I am Anthony Caterson
So sometimes it’s hard to explain what benefits I feel from taking dioxyme brain nootropic
I have since purchasing Brain have been taking them and feel great and looking great
I accompany these with the CLA & the fat loss
Staying with workouts 1-2 times a day
Thank you dioxyme

Tony needs help losing lonjas
They work

Had my doubts about these supplements. However. After my. 10 day trail doses , I realized. How unfocused and. Exhausted. I was without them ( college student ).
Great product !!

Rick Sandretto
Interesting Stuff

Bought this a couple weeks ago and have used it about 4 different days. Usually take 2 in the early afternoon. Definitely feel the energy. It’s just not a caffeine jolt but a bit of a brain activity booster.

Jacque Johnson
Was skeptical

Now I’m not. Good stuff, best of all no jitters. My coffee consumption has dropped by productivity keep going up. Well done

Nina Strand
Products I Love CLA and FAT LOSS

You sent it to me a little too soon but I’m ok with it. I know you’ll send me a reminder🙄


1. Spiers, Paul & Myers, Diane & Hochanadel, Gail & Lieberman, Harris & Wurtman, Judith. (1996). Citi***** Improves Verbal Memory in Aging. Archives of neurology. 53. 441-8. 10.1001/archneur.1996.00550050071026.

2. Alvarez, Xose & Laredo, M & Corzo, Diana & Fernandez-Novoa, Lucia & Mouzo, Ricardo & Perea, J & Daniele, D & Cacabelos, Ramon. (1997). Citi***** improves memory performance in elderly subjects. Methods and findings in experimental and clinical pharmacology. 19. 201-10.

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4. Tayebati, Seyed Khosrow & Tomassoni, Daniele & Nwankwo, Ejike Innocent & Di Stefano, Antonio & Sozio, Piera & Cerasa, Laura & Amenta, Francesco. (2012). Modulation Of Monoaminergic Transporters By Choline-Containing Phospholipids In Rat Brain.. CNS & neurological disorders drug targets. 12. 10.2174/1871527311312010015.

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8. Villa, Roberto & Ferrari, Federica & Gorini, Antonella. (2011). Effect of In Vivo l-Acetylcarnitine Administration on ATP-ases Enzyme Systems of Synaptic Plasma Membranes from Rat Cerebral Cortex. Neurochemical research. 36. 1372-82. 10.1007/s11064-011-0462-x.

9. Dolezal, Vladimír & Tuček, Stanislav. (2006). Utilization of Citrate, Acetylcarnitine, Acetate, Pyruvate and Glucose for the Synthesis of Acetylcholine in Rat Brain Slices. Journal of Neurochemistry. 36. 1323 - 1330. 10.1111/j.1471-4159.1981.tb00569.x.

10. Lombard, KA & Olson, Ann & Nelson, Steven & Rebouche, C. (1989). Carnitine status of lactoovovegetarians and strict vegetarian adults and children. The American journal of clinical nutrition. 50. 301-6. 10.1093/ajcn/50.2.301.

11. Dhitavat, Sirakarnt & Ortiz, Daniela & Shea, Thomas & Rivera, Ezequiel. (2002). Acetyl-l-Carnitine Protects Against Amyloid-Beta Neurotoxicity: Roles of Oxidative Buffering and ATP Levels. Neurochemical research. 27. 501-5. 10.1023/A:1019800703683.

12. Wawrzeńczyk, Agnieszka & Nałęcz, Katarzyna & Nałecz, M. (1995). Effect of externally added carnitine on the synthesis of acetylcholine in rat cerebral cortex cells. Neurochemistry international. 26. 635-41. 10.1016/0197-0186(94)00162-N.

13. Cha, Y & Choi, S & SUH, Heajung & Lee, S & CHO, Dongyoung & Li, K. (2002). Effects of Carnitine Coingested Caffeine on Carnitine Metabolism and Endurance Capacity in Athletes.. Journal of nutritional science and vitaminology. 47. 378-84. 10.3177/jnsv.47.378.

14. Oudheusden, L.J. & Scholte, H.R.. (2002). Efficacy of carnitine in the treatment of children with attention-deficit hyperactivity disorder. Prostaglandins, leukotrienes, and essential fatty acids. 67. 33-8. 10.1054/plef.2002.0378.

15. Rebouche, C. (1993). Carnitine function and requirements during the life. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 6. 3379-86. 10.1096/fasebj.6.15.1464372.

16. Banderet, Louis & Lieberman, Harris. (1989). Treatment with tyrosine, a neurotransmitter precursor, reduces environmental stress in humans. Brain research bulletin. 22. 759-62. 10.1016/0361-9230(89)90096-8.

17. Shurtleff, David & Thomas, John & Schrot, John & Kowalski, Kathleen & Harford, Robert. (1994). Tyrosine reverses a cold-induced working memory deficit in humans. Pharmacology, biochemistry, and behavior. 47. 935-41. 10.1016/0091-3057(94)90299-2.

18. Zaragoza, Javier & Tinsley, Grant & Urbina, Stacie & Villa, Katelyn & Santos, Emily & Juaneza, Angelie & Tinnin, Matthias & Davidson, Cory & Mitmesser, Susan & Zhang, Zhiying & Taylor, Lem. (2019). Effects of acute caffeine, theanine and tyrosine supplementation on mental and physical performance in athletes. Journal of the International Society of Sports Nutrition. 16. 10.1186/s12970-019-0326-3.

19. Colzato, Lorenza & Jongkees, Bryant & Sellaro, Roberta & Hommel, Bernhard. (2013). Working Memory Reloaded: Tyrosine Repletes Updating in the N-Back Task. Frontiers in behavioral neuroscience. 7. 200. 10.3389/fnbeh.2013.00200.

20. Neri, D & Wiegmann, Douglas & Stanny, R & Shappell, Scott & McCardie, A & McKay, D. (1995). The effects of tyrosine on cognitive performance during extended wakefulness. Aviation, space, and environmental medicine. 66. 313-9.

21. Thomas, John & Lockwood, Park & Singh, Anita & Deuster, Patricia. (1999). Tyrosine Improves Working Memory in a Multitasking Environment. Pharmacology, biochemistry, and behavior. 64. 495-500. 10.1016/S0091-3057(99)00094-5.

22. Fernstrom, John & Fernstrom, Madelyn. (2007). Tyrosine, Phenylalanine, and Catecholamine Synthesis and Function in the Brain. The Journal of nutrition. 137. 1539S-1547S; discussion 1548S. 10.1093/jn/137.6.1539S.

23. Lehnert, Hendrik & Wurtman, R. (1993). Amino Acid Control of Neurotransmitter Synthesis and Release: Physiological and Clinical Implications. Psychotherapy and psychosomatics. 60. 18-32. 10.1159/000288676.

24. LIEBERMAN, HR. (1995). PERFORMANCE ENHANCING FOOD COMPONENTS. ACS National Meeting Book of Abstracts. 209. 34-AGFD.

25. Childs, Emma & Wit, Harriet. (2006). Subjective, behavioral, and physiological effects of acute caffeine in light, nondependent caffeine users. Psychopharmacology. 185. 514-23. 10.1007/s00213-006-0341-3.

26. Smillie, Luke & Gokcen, Elif. (2010). Caffeine enhances working memory for extraverts. Biological psychology. 85. 496-8. 10.1016/j.biopsycho.2010.08.012.

27. Backhouse, Susan & Biddle, Stuart & Bishop, Nicolette & Williams, Clyde. (2011). Caffeine ingestion, affect and perceived exertion during prolonged cycling. Appetite. 57. 247-52. 10.1016/j.appet.2011.05.304.

28. Higashiyama, Akiko & Htay, Hla Hla & Ozeki, Makoto & Juneja, Lekh & Kapoor, Mahendra. (2011). Effects of L-theanine on attention and reaction time response. Journal of Functional Foods. 3. 171-178. 10.1016/j.jff.2011.03.009.

29. Tamano, Haruna & Fukura, Kotaro & Suzuki, Miki & Sakamoto, Kazuhiro & Yokogoshi, Hidehiko & Takeda, Atsushi. (2013). Preventive Effect of Theanine Intake on Stress-induced Impairments of Hippocamapal Long-term Potentiation and Recognition Memory.. Brain research bulletin. 95. 10.1016/j.brainresbull.2013.02.005.

30. Owen, Gail & Parnell, Holly & Bruin, Eveline & Rycroft, Jane. (2008). The combined effects of L-theanine and caffeine on cognitive performance and mood. Nutritional neuroscience. 11. 193-8. 10.1179/147683008X301513.

* These statements have not been evaluated by the FDA. Our products are not intended to diagnose, treat, cure, or prevent any disease.

** Most users feel a noticeable effect within 30-45 minutes. Results may vary based on your tolerance and use of caffeine.

Warning Prop 65 for California Residents: This product may expose you to chemicals which are known to the State of California to cause cancer and birth defects or other reproductive harm. For more information, go to


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