Marc S. Schneider, M.D.
What Is Muscle Protein Optimizer | MPO?
Muscle Protein Optimizer (MPO) is designed to combine the 5 most effective, natural, anabolic, and ergogenic ingredients in one supplement.
Creatine is considered by most sports nutrition experts to be the MOST EFFECTIVE supplement for increasing high-intensity exercise capacity, building muscle mass, speed, and strength. Studies have demonstrated lean muscle gains of 2-5 pounds in 1-3 months 3-5 grams of creatine a day and training. Creatine supplementation also results in improved neuromuscular and anaerobic gains. while lessening the risk of injury during training. Long-term studies reveal no side effects from its use.
Creatine has often been cited for causing increased water retention. However, Powers et. al. reporting in the Journal of Athletic Training, demonstrated that compared to placebo, creatine supplementation only increased total body water by 2 pounds in trained athletes. Thus for physique athletes prepping for a contest, it might be wise to stop creatine several weeks before their show.
β-hydroxy β-methylbutyrate (HMB)
HMB is formed from the body’s metabolism of leucine. Supplementation with adequate doses of HMB daily for 3-6 weeks during training has been clinically shown to increase muscle mass gains by over 1-2 pounds more than the gains in similarly trained athletes taking a placebo. HMB also improves training adaptation during intense exercise and decreases muscle catabolic breakdown.
ɑ-hydroxy-isocaproic acid (HICA)
HICA is another metabolite of leucine. Supplementation with HICA during intense training has been shown to significantly increase lean muscle mass. In addition, HICA, like BCAA’s, can significantly decrease delayed onset muscle soreness (DOMS) caused by training. HICA also helps prevent the breakdown of muscle protein and is anti-catabolic. Please refer to our Ultimate Guide on HICA for an in-depth analysis of this anabolic ingredient.
Beta-alanine has been demonstrated to increase athletic endurance of both anaerobic and aerobic athletic activities. It does this by buffering the muscular environment to lactic acid build up. Thus, athletes consuming beta-alanine can exercise harder and longer.
Phosphatidic Acid (PA)
PA is an anabolic stimulator that causes muscle hypertrophy and strength gains. mTOR has been shown to regulate the rate of muscle protein synthesis and resistance exercise activates mTOR. A key component of this mTOR activation is the cofactor phosphatidic acid. Studies demonstrate that supplementing athletes with adequate doses of PA significantly improved muscle mass and anaerobic power while decreasing fat.