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Fat Loss Oxidize Fat


FAT LOSS is a thermogenic supplement that stimulates your body’s ability to burn fat both during exercise and at rest. Its all-natural ingredients work not only by promoting the breakdown of body fat but also by improving your metabolism and appetite control.*

A fat loss formula that actually works.

  • safely lose weight with scientific trial-proven ingredients
  • unique formula with patented timed-release caffeine
  • help suppress appetite
  • 30-day supply
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View Comparison Chart
# of Effective
# of Ingredients
Lacking Support
# of Low-Dosed
5 0 0 n/a
AlaniNuFat Burner 1 3 2 n/a
EVLTransform 4 2 5 unsafe
HydroxycutHardcore Elite 2 3 1 unsafe
Nobi NutritionPremium Fat Burner 0 3 0 n/a
Old SchoolVintage Burn 2 0 7 n/a
PhenQWeight Loss Pills 2 1 2 prop blend
RSPQuadralean 1 2 3 n/a
Sascha FitnessFit 9 2 0 5 banned

Disclaimer. Dioxyme is not affiliated with the brands in this comparison chart.

Lacking Support. there is not a preponderance of scientific studies demonstrating the effectiveness of the ingredient.

Low-Dosed. Dosages are below recommended dosages for effect.

Unsafe Risks The product mentioned uses Yohimbe, an ingredient associated with abnormal and overly fast heart rates, heart attack, chest pain, anxiety, and high blood pressure.

Ingredient Transparency

All natural ingredients with eco-friendly packaging. We never use synthetics, or unneeded fillers.

  • vegan
  • all natural
  • eco friendly
  • non gmo
  • gluten free

Our Ingredients

We use trial-proven ingredients at clinically-backed doses that produce measurable results. We never hide behind prop blends or label loopholes.



L-Tyrosine is a naturally occurring amino acid that is found in low doses in a number of foods including meat, fish, eggs, dairy, nuts, legumes, and oats. It is essential to your body's production of several key neurotransmitters known as catecholamines.

With that said, L-tyrosine supports fat loss via 2 mechanisms:

L-Tyrosine is an excellent appetite suppressant.1,2
L-Tyrosine also helps fat loss via stimulating fat release from fat cells.3,4

It should be noted that L-Tyrosine is also important to the function of your thyroid gland. The thyroid gland controls your metabolic rate and thus helps you burn the calories from your meals as energy. Burning more calories ultimately helps with weight loss.5

We should also mention, that when certain ingredients are combined, there are synergistic effects that take place. For instance, when L-Tyrosine is combined with co-factor Vitamin B6, specific catecholamine production is increased. This helps with weight loss. Additionally, the combination of L-Tyrosine and caffeine has been shown to synergistically increase fat burning. Of course, Fat Loss contains L-Tyrosine, Vitamin B6, and caffeine to maximize its weight loss potential.1,2,6

Timed-Release Caffeine


Caffeine is a thermogenic that boosts your metabolism, increases fat burning, and reduces appetite.7

Thermogenic literally means heat-producing. When your body burns calories, it generates heat. Therefore, supplements that boost your metabolism and increase fat burning are known as thermogenics.

Caffeine works by increasing the release of neurotransmitters in the bloodstream. The release of some neurotransmitters make you feel more awake and energized, while the release of others stimulates the nervous system. Specifically, caffeine causes neurotransmitters to travel through your blood to the fat tissues, signaling them to break down fats and release them into your bloodstream where they can be used for energy.8,9,10

Since caffeine makes you feel more awake and energized, studies show that it may improve exercise performance by 11–12%.11,12

Additionally, it should be noted that the rate you burn calories while resting is known as your resting metabolic rate (RMR). The higher your metabolic rate, the easier it is for you to lose weight, and the more you can eat without gaining weight. Studies show that caffeine can increase your RMR by 3–11%. Interestingly, most of the increase in metabolism is caused by an increase in fat burning.13,14,15

EGCG (Epigallocatechin gallate)


EGCG is a plant-based compound known as a catechin. EGCG and other related catechins can boost your metabolism, and act as potent antioxidants that may protect against cellular damage caused by free radicals. EGCG happens to be the most researched and potent catechin.16

EGCG can be found in many natural foods, and it is the major active compound found in green tea. Green tea, of course, is known for its weight loss properties because it contains two thermogenic compounds: caffeine and EGCG. As noted above, caffeine stimulates the release of adrenaline, which boosts metabolism and increases fat burning. EGCG enhances these effects by slowing the breakdown of adrenaline so that its impact is amplified.17,18,19

Interestingly, research has found that caffeinated green tea supplements can increase metabolism by roughly 4%, and boost fat burning by 16% for 24 hours after ingestion. Additionally, studies show that EGCG increases fat oxidation during fasted states, resting states, and during exercise. Further, long term use of EGCG can change how fat metabolism genes work and result in an increase in fat metabolism and the lowering of fat storage genes in the liver.20,21

5-HTP (5-Hydroxytryptophan)


5-HTP helps encourage weight loss because it is an excellent appetite suppressant. Specifically, weight loss can increase the production of hormones that make you feel hungry. 5-HTP counteracts these hunger-inducing hormones. This will help you lose weight in the short term, and it will help you maintain your weight loss in the long term.22,23,24,25

In addition, 5-HTP inhibits the intake of calories from carbohydrates, which is associated with better blood sugar control. Better blood sugar control helps maintain ideal body composition.26

5-HTP is an amino acid that your body naturally produces, which in turn produces serotonin, a chemical messenger that sends signals between your nerve cells. It is important to ensure our bodies have the proper levels of 5-HTP as low serotonin levels are associated with weight gain and other health problems.27,28

Vitamin B6


Vitamin B6 is a water-soluble vitamin that your body needs for optimal health and for several bodily functions. It’s significant to the creation of critical hormones, such as the thyroid hormone, red blood cells and neurotransmitters. It is also plays an important role in protein, fatty acid, and carbohydrate metabolism. Since, Vitamin B6 improves the efficiency of carbohydrate metabolism, it helps maintain lean body composition.29,30

It should also be noted that Vitamin B6 is a co-factor along with Tyrosine in the manufacture of catecholamines, which further helps with fat loss.1

Unfortunately, your body cannot produce vitamin B6 on its own, so it is essential that you consume adequately from food or supplements.



The antioxidant Fucoxanthin is a natural substance and a member of the carotenoid family. It is found in some types of seaweed, such as wakame. Fucoxanthin is excellent for weight loss for numerous reasons.

To start with, fucoxanthin speeds up your resting metabolism by upregulating the unique protein UCP1. Your resting metabolism is what you normally burn while doing minimal physical activity. This means that fucoxanthin can help with weight loss even when you are not exercising.31

Next, fucoxanthin inhibits the formation of new fat cells, and it inhibits fat accumulation in those cells. Studies actually show that fucoxanthin can inhibit the buildup of abdominal fat, and can reduce the buildup of fat in the liver.32

Additionally, research suggests fucoxanthin is an excellent appetite suppressor since it affects the body’s levels of leptin, a hormone essential to hunger control.33

Finally, in a recent study, the use of fucoxanthin for weight loss was also associated with an improved lipid plasma profile.34

Suggested Use


Take (1) capsule of FAT LOSS twice daily. Since FAT LOSS contains patented timed-release caffeine, we suggest you do not take it within 6 hours of bedtime.

When to Take It

in the morning: Take FAT LOSS in the morning when you first wake up. FAT LOSS can be taken with food or on an empty stomach. beginning of the afternoon: Take FAT LOSS around 1-2 pm. Again FAT LOSS can be taken after lunch or on an empty stomach.

Peace of Mind

The supplement industry is full of gimmicks, unsubstantiated claims, and unsafe products. We’re here to put your mind at ease.

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Customer Reviews

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1. Fernstrom, John & Fernstrom, M. (2001). Monoamines and Protein Intake: Are Control Mechanisms Designed to Monitor a Threshold Intake or a Set Point?. Nutrition reviews. 59. S60-5; discussion S66. 10.1111/j.1753-4887.2001.tb05502.x.

2. Møller SE, Maach-Møller B, Olesen M, Madsen B, Madsen P, Fjalland B. Tyrosine metabolism in users of oral contraceptives. Life Sci. 1995;56(9):687-95. doi: 10.1016/0024-3205(94)00502-j. PMID: 7869850.

3. Meijssen S, Cabezas MC, Ballieux CG, Derksen RJ, Bilecen S, Erkelens DW. Insulin mediated inhibition of hormone sensitive lipase activity in vivo in relation to endogenous catecholamines in healthy subjects. J Clin Endocrinol Metab. 2001 Sep;86(9):4193-7. doi: 10.1210/jcem.86.9.7794. PMID: 11549649.

4. Murray R.K, , Granner D. K., Harper's Biochemistry, 23-rd edition, Ch 27 lipid transport and storage.

5. Nannipieri M, Cecchetti F, Anselmino M, Camastra S, Niccolini P, Lamacchia M, Rossi M, Iervasi G, Ferrannini E. Expression of thyrotropin and thyroid hormone receptors in adipose tissue of patients with morbid obesity and/or type 2 diabetes: effects of weight loss. Int J Obes (Lond). 2009 Sep;33(9):1001-6. doi: 10.1038/ijo.2009.140. Epub 2009 Jul 28. Erratum in: Int J Obes (Lond). 2010 Jan;34(1):215. PMID: 19636322.

6. Belza A, Frandsen E, Kondrup J. Body fat loss achieved by stimulation of thermogenesis by a combination of bioactive food ingredients: a placebo-controlled, double-blind 8-week intervention in obese subjects. Int J Obes (Lond). 2007 Jan;31(1):121-30. doi: 10.1038/sj.ijo.0803351. Epub 2006 Apr 25. PMID: 16652130.

7. Harpaz E, Tamir S, Weinstein A, Weinstein Y. The effect of caffeine on energy balance. J Basic Clin Physiol Pharmacol. 2017 Jan 1;28(1):1-10. doi: 10.1515/jbcpp-2016-0090. PMID: 27824614.

8. Kim, T., Shin, Y., Lee, J. et al. Effect of caffeine on the metabolic responses of lipolysis and activated sweat gland density in human during physical activity. Food Sci Biotechnol 19, 1077–1081 (2010). https://doi.org/10.1007/s10068-010-0151-6

9. Keijzers GB, De Galan BE, Tack CJ, Smits P. Caffeine can decrease insulin sensitivity in humans. Diabetes Care. 2002 Feb;25(2):364-9. doi: 10.2337/diacare.25.2.364. PMID: 11815511.

10. Anderson DE, Hickey MS. Effects of caffeine on the metabolic and catecholamine responses to exercise in 5 and 28 degrees C. Med Sci Sports Exerc. 1994 Apr;26(4):453-8. PMID: 8201901.

11. Doherty M, Smith PM. Effects of caffeine ingestion on rating of perceived exertion during and after exercise: a meta-analysis. Scand J Med Sci Sports. 2005 Apr;15(2):69-78. doi: 10.1111/j.1600-0838.2005.00445.x. PMID: 15773860.

12. Doherty M, Smith PM. Effects of caffeine ingestion on exercise testing: a meta-analysis. Int J Sport Nutr Exerc Metab. 2004 Dec;14(6):626-46. doi: 10.1123/ijsnem.14.6.626. PMID: 15657469.

13. Dulloo AG, Geissler CA, Horton T, Collins A, Miller DS. Normal caffeine consumption: influence on thermogenesis and daily energy expenditure in lean and postobese human volunteers. Am J Clin Nutr. 1989 Jan;49(1):44-50. doi: 10.1093/ajcn/49.1.44. PMID: 2912010.

14. Koot P, Deurenberg P. Comparison of changes in energy expenditure and body temperatures after caffeine consumption. Ann Nutr Metab. 1995;39(3):135-42. doi: 10.1159/000177854. PMID: 7486839.

15. Acheson KJ, Gremaud G, Meirim I, Montigon F, Krebs Y, Fay LB, Gay LJ, Schneiter P, Schindler C, Tappy L. Metabolic effects of caffeine in humans: lipid oxidation or futile cycling? Am J Clin Nutr. 2004 Jan;79(1):40-6. doi: 10.1093/ajcn/79.1.40. PMID: 14684395.

16. Kim HS, Quon MJ, Kim JA. New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate. Redox Biol. 2014 Jan 10;2:187-95. doi: 10.1016/j.redox.2013.12.022. PMID: 24494192; PMCID: PMC3909779.

17. Dulloo AG, Seydoux J, Girardier L, Chantre P, Vandermander J. Green tea and thermogenesis: interactions between catechin-polyphenols, caffeine and sympathetic activity. Int J Obes Relat Metab Disord. 2000 Feb;24(2):252-8. doi: 10.1038/sj.ijo.0801101. PMID: 10702779.

18. Shixian Q, VanCrey B, Shi J, Kakuda Y, Jiang Y. Green tea extract thermogenesis-induced weight loss by epigallocatechin gallate inhibition of catechol-O-methyltransferase. J Med Food. 2006 Winter;9(4):451-8. doi: 10.1089/jmf.2006.9.451. PMID: 17201629.

19. Rains TM, Agarwal S, Maki KC. Antiobesity effects of green tea catechins: a mechanistic review. J Nutr Biochem. 2011 Jan;22(1):1-7. doi: 10.1016/j.jnutbio.2010.06.006. Epub 2010 Nov 5. PMID: 21115335.

20. Hursel R, Viechtbauer W, Dulloo AG, Tremblay A, Tappy L, Rumpler W, Westerterp-Plantenga MS. The effects of catechin rich teas and caffeine on energy expenditure and fat oxidation: a meta-analysis. Obes Rev. 2011 Jul;12(7):e573-81. doi: 10.1111/j.1467-789X.2011.00862.x. Epub 2011 Mar 2. PMID: 21366839.

21. Hodgson AB, Randell RK, Jeukendrup AE. The effect of green tea extract on fat oxidation at rest and during exercise: evidence of efficacy and proposed mechanisms. Adv Nutr. 2013 Mar 1;4(2):129-40. doi: 10.3945/an.112.003269. PMID: 23493529; PMCID: PMC3649093.

22. Coutinho SR, Rehfeld JF, Holst JJ, Kulseng B, Martins C. Impact of weight loss achieved through a multidisciplinary intervention on appetite in patients with severe obesity. Am J Physiol Endocrinol Metab. 2018 Jul 1;315(1):E91-E98. doi: 10.1152/ajpendo.00322.2017. Epub 2018 Jan 23. PMID: 29360396.

23. Martins C, Kulseng B, King NA, Holst JJ, Blundell JE. The effects of exercise-induced weight loss on appetite-related peptides and motivation to eat. J Clin Endocrinol Metab. 2010 Apr;95(4):1609-16. doi: 10.1210/jc.2009-2082. Epub 2010 Feb 11. PMID: 20150577.

24. King NA, Caudwell PP, Hopkins M, Stubbs JR, Naslund E, Blundell JE. Dual-process action of exercise on appetite control: increase in orexigenic drive but improvement in meal-induced satiety. Am J Clin Nutr. 2009 Oct;90(4):921-7. doi: 10.3945/ajcn.2009.27706. Epub 2009 Aug 12. PMID: 19675105.

25. Heisler LK, Jobst EE, Sutton GM, Zhou L, Borok E, Thornton-Jones Z, Liu HY, Zigman JM, Balthasar N, Kishi T, Lee CE, Aschkenasi CJ, Zhang CY, Yu J, Boss O, Mountjoy KG, Clifton PG, Lowell BB, Friedman JM, Horvath T, Butler AA, Elmquist JK, Cowley MA. Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron. 2006 Jul 20;51(2):239-49. doi: 10.1016/j.neuron.2006.06.004. PMID: 16846858.

26. Cangiano C, Laviano A, Del Ben M, Preziosa I, Angelico F, Cascino A, Rossi-Fanelli F. Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients. Int J Obes Relat Metab Disord. 1998 Jul;22(7):648-54. doi: 10.1038/sj.ijo.0800642. PMID: 9705024.

27. Vashadze ShV. [Insomnia, serotonin and depression]. Georgian Med News. 2007 Sep;(150):22-4. Russian. PMID: 17984558.

28. Wurtman RJ, Wurtman JJ. Brain serotonin, carbohydrate-craving, obesity and depression. Obes Res. 1995 Nov;3 Suppl 4:477S-480S. doi: 10.1002/j.1550-8528.1995.tb00215.x. PMID: 8697046.

29. JOHN F. MUELLER, M.D., JAMES M. IACONO, PH.D., Effect of Desoxypyridoxine-Induced Vitamin B6 Deficiency on Polyunsaturated Fatty Acid Metabolism in Human Beings, The American Journal of Clinical Nutrition, Volume 12, Issue 5, May 1963, Pages 358–367, https://doi.org/10.1093/ajcn/12.5.358

30. National Institutes of Health: Office of Dietary Supplements. Vitamin B6.

31. Maeda H, Hosokawa M, Sashima T, Funayama K, Miyashita K. Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues. Biochem Biophys Res Commun. 2005 Jul 1;332(2):392-7. doi: 10.1016/j.bbrc.2005.05.002. PMID: 15896707.

32. Maeda H, Hosokawa M, Sashima T, Takahashi N, Kawada T, Miyashita K. Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells. Int J Mol Med. 2006 Jul;18(1):147-52. PMID: 16786166.

33. Gammone MA, D'Orazio N. Anti-obesity activity of the marine carotenoid fucoxanthin. Mar Drugs. 2015 Apr 13;13(4):2196-214. doi: 10.3390/md13042196. PMID: 25871295; PMCID: PMC4413207.

34. Abidov M, Ramazanov Z, Seifulla R, Grachev S. The effects of Xanthigen in the weight management of obese premenopausal women with non-alcoholic fatty liver disease and normal liver fat. Diabetes Obes Metab. 2010 Jan;12(1):72-81. doi: 10.1111/j.1463-1326.2009.01132.x. Epub 2009 Oct 13. PMID: 19840063.

* These statements have not been evaluated by the FDA. Our products are not intended to diagnose, treat, cure, or prevent any disease.

Warning Prop 65 for California Residents: This product may expose you to chemicals which are known to the State of California to cause cancer and birth defects or other reproductive harm. For more information, go to https://www.p65warnings.ca.gov/.


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