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Fat Loss Oxidize Fat

$49.99 or $49.99 $44.99 / month

FAT LOSS is a thermogenic supplement that stimulates your body’s ability to burn fat both during exercise and at rest. Its all-natural ingredients work not only by promoting the breakdown of body fat but also by improving your metabolism and appetite control.*

A fat loss formula that actually works.

  • safely lose weight with scientific trial-proven ingredients
  • unique formula with patented timed-release caffeine
  • help suppress appetite
  • 30-day supply
- +

Free Shipping & 100% Satisfaction Guarantee
View Comparison Chart
Long-Lasting
Energy
# of Effective
Ingredients
# of Ingredients
Lacking Support
# of Low-Dosed
Ingredients
Other
5 0 0 n/a
AlaniNuFat Burner 1 3 2 n/a
EVLTransform 4 2 5 risks
HydroxycutHardcore Elite 2 3 1 risks
Nobi NutritionPremium Fat Burner 0 3 0 n/a
Old SchoolVintage Burn 2 0 7 n/a
PhenQWeight Loss Pills 2 1 2 prop blend
RSPQuadralean 1 2 3 n/a
Sascha FitnessFit 9 2 0 5 banned
substances

Disclaimer. Dioxyme is not affiliated with the brands in this comparison chart.

Lacking Support. there is not a preponderance of scientific studies demonstrating the effectiveness of the ingredient.

Low-Dosed. Dosages are below recommended dosages for effect.

Risks The product mentioned uses Yohimbe, an ingredient that has been associated with abnormal and overly fast heart rates, heart attack, chest pain, anxiety, and high blood pressure.

Banned Substances Contains substances on the WADA and USADA banned substance list.

Ingredient Transparency

All natural ingredients with eco-friendly packaging. We never use synthetics, or unneeded fillers.

  • vegan
  • all natural
  • eco friendly
  • non gmo
  • gluten free

Our Ingredients

We use trial-proven ingredients at clinically-backed doses that produce measurable results. We never hide behind prop blends or label loopholes.

Apple Cider Vinegar

200mg

Apple Cider Vinegar has been used as a health supplement for thousands of years. An organic compound named acetic acid, also known as ethanoic acid, is the main active component in Apple Cider Vinegar.

The acetic acid in Apple Cider Vinegar supports fat loss via multiple mechanisms:

Improves metabolism 1
Reduces fat storage 2,3
Burns fat 4
Suppresses appetite 5

Other studies suggest that Apple Cider Vinegar also promotes fullness, which in turn can decrease caloric intake. Additionally, research shows that Apple Cider Vinegar slows the rate at which food leaves your stomach. This improves fullness, and helps to lowers blood sugar and insulin levels.6,7,8

Timed-Release Caffeine

175mg

Caffeine is a thermogenic that boosts your metabolism, increases fat burning, and reduces appetite.9

Thermogenic literally means heat-producing. When your body burns calories, it generates heat. Therefore, supplements that boost your metabolism and increase fat burning are known as thermogenics.

Caffeine works by increasing the release of neurotransmitters in the bloodstream. The release of some neurotransmitters make you feel more awake and energized, while the release of others stimulates the nervous system. Specifically, caffeine causes neurotransmitters to travel through your blood to the fat tissues, signaling them to break down fats and release them into your bloodstream where they can be used for energy.10,11,12

Since caffeine makes you feel more awake and energized, studies show that it may improve exercise performance by 11–12%.13,14

Additionally, it should be noted that the rate you burn calories while resting is known as your resting metabolic rate (RMR). The higher your metabolic rate, the easier it is for you to lose weight, and the more you can eat without gaining weight. Studies show that caffeine can increase your RMR by 3–11%. Interestingly, most of the increase in metabolism is caused by an increase in fat burning.15,16,17

EGCG (Epigallocatechin gallate)

150mg

EGCG is a plant-based compound known as a catechin. EGCG and other related catechins can boost your metabolism, and act as potent antioxidants that may protect against cellular damage caused by free radicals. EGCG happens to be the most researched and potent catechin.18

EGCG can be found in many natural foods, and it is the major active compound found in green tea. Green tea, of course, is known for its weight loss properties because it contains two thermogenic compounds: caffeine and EGCG. As noted above, caffeine stimulates the release of adrenaline, which boosts metabolism and increases fat burning. EGCG enhances these effects by slowing the breakdown of adrenaline so that its impact is amplified.19,20,21

Interestingly, research has found that caffeinated green tea supplements can increase metabolism by roughly 4%, and boost fat burning by 16% for 24 hours after ingestion. Additionally, studies show that EGCG increases fat oxidation during fasted states, resting states, and during exercise. Further, long term use of EGCG can change how fat metabolism genes work and result in an increase in fat metabolism and the lowering of fat storage genes in the liver.22,23

5-HTP (5-Hydroxytryptophan)

50mg

5-HTP helps encourage weight loss because it is an excellent appetite suppressant. Specifically, weight loss can increase the production of hormones that make you feel hungry. 5-HTP counteracts these hunger-inducing hormones. This will help you lose weight in the short term, and it will help you maintain your weight loss in the long term.24,25,26,27

In addition, 5-HTP inhibits the intake of calories from carbohydrates, which is associated with better blood sugar control. Better blood sugar control helps maintain ideal body composition.28

5-HTP is an amino acid that your body naturally produces, which in turn produces serotonin, a chemical messenger that sends signals between your nerve cells. It is important to ensure our bodies have the proper levels of 5-HTP as low serotonin levels are associated with weight gain and other health problems.29,30

Vitamin B6

15mg

Vitamin B6 is a water-soluble vitamin that your body needs for optimal health and for several bodily functions. It’s significant to the creation of critical hormones, such as the thyroid hormone, red blood cells and neurotransmitters. It is also plays an important role in protein, fatty acid, and carbohydrate metabolism. Since, Vitamin B6 improves the efficiency of carbohydrate metabolism, it helps maintain lean body composition.31,32

Unfortunately, your body cannot produce vitamin B6 on its own, so it is essential that you consume adequately from food or supplements.

Fucoxanthin

4mg

The antioxidant Fucoxanthin is a natural substance and a member of the carotenoid family. It is found in some types of seaweed, such as wakame. Fucoxanthin is excellent for weight loss for numerous reasons.

To start with, fucoxanthin speeds up your resting metabolism by upregulating the unique protein UCP1. Your resting metabolism is what you normally burn while doing minimal physical activity. This means that fucoxanthin can help with weight loss even when you are not exercising.33

Next, fucoxanthin inhibits the formation of new fat cells, and it inhibits fat accumulation in those cells. Studies actually show that fucoxanthin can inhibit the buildup of abdominal fat, and can reduce the buildup of fat in the liver.34

Additionally, research suggests fucoxanthin is an excellent appetite suppressor since it affects the body’s levels of leptin, a hormone essential to hunger control.35

Finally, in a recent study, the use of fucoxanthin for weight loss was also associated with an improved lipid plasma profile.36

Suggested Use

Directions

Take (1) capsule of FAT LOSS twice daily. Since FAT LOSS contains patented timed-release caffeine, we suggest you do not take it within 6 hours of bedtime.

When to Take It

in the morning: Take FAT LOSS in the morning when you first wake up. FAT LOSS can be taken with food or on an empty stomach. beginning of the afternoon: Take FAT LOSS around 1-2 pm. Again FAT LOSS can be taken after lunch or on an empty stomach.

Peace of Mind

The supplement industry is full of gimmicks, unsubstantiated claims, and unsafe products. We’re here to put your mind at ease.

  • physician
    formulated
  • pro athlete
    validated
  • family
    owned
  • made in
    the USA

FAQ's

Customer Reviews

Based on 59 reviews
78%
(46)
20%
(12)
2%
(1)
0%
(0)
0%
(0)
M
M.R.
Well done

I haven’t lost weight but I feel less puffy! Looking forward to keeping up with this supplement

H
H.B.
Great product

Not going to lie, I was skeptical at first, but this is a great appetite suppressant. Although I have not lost weight (only been taking it for 2 weeks), I have maintained & had extra energy for my workouts. Will definitely purchase again!

D
D.R.
Amazing Product

Amazing Product

M
M.H.
Still early but hopefully good results !

Just started the product as I started my vacation hoping to divert a massive weight gain. No side effects and easy to take. I have been on CLA with good results and hoping the stack will take me to the next level.

N
N.
Really works

At first I was skeptical to use it,but it works very well as an appetite suppressant and also it does not give any jittery feeling nor any headaches. I would definitely recommend it for anyone who is looking to loose that stubborn pounds. Along with the Fat stacker you need to exercise and eat sensibly.

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References

1. Sakakibara S, Yamauchi T, Oshima Y, Tsukamoto Y, Kadowaki T. Acetic acid activates hepatic AMPK and reduces hyperglycemia in diabetic KK-A(y) mice. Biochem Biophys Res Commun. 2006 Jun 2;344(2):597-604. doi: 10.1016/j.bbrc.2006.03.176. Epub 2006 Apr 5. PMID: 16630552.

2. Yamashita H. Biological Function of Acetic Acid-Improvement in Obesity and Glucose Tolerance by Acetic Acid in Type 2 Diabetic Rats. Crit Rev Food Sci Nutr. 2016 Jul 29;56 Suppl 1:S171-5. doi: 10.1080/10408398.2015.1045966. PMID: 26176799.

3. Yamashita H, Fujisawa K, Ito E, Idei S, Kawaguchi N, Kimoto M, Hiemori M, Tsuji H. Improvement of obesity and glucose tolerance by acetate in Type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Biosci Biotechnol Biochem. 2007 May;71(5):1236-43. doi: 10.1271/bbb.60668. Epub 2007 May 7. PMID: 17485860.

4. Kondo T, Kishi M, Fushimi T, Kaga T. Acetic acid upregulates the expression of genes for fatty acid oxidation enzymes in liver to suppress body fat accumulation. J Agric Food Chem. 2009 Jul 8;57(13):5982-6. doi: 10.1021/jf900470c. PMID: 19469536.

5. Frost G, Sleeth ML, Sahuri-Arisoylu M, Lizarbe B, Cerdan S, Brody L, Anastasovska J, Ghourab S, Hankir M, Zhang S, Carling D, Swann JR, Gibson G, Viardot A, Morrison D, Louise Thomas E, Bell JD. The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism. Nat Commun. 2014 Apr 29;5:3611. doi: 10.1038/ncomms4611. PMID: 24781306; PMCID: PMC4015327.

6. Darzi J, Frost GS, Montaser R, Yap J, Robertson MD. Influence of the tolerability of vinegar as an oral source of short-chain fatty acids on appetite control and food intake. Int J Obes (Lond). 2014 May;38(5):675-81. doi: 10.1038/ijo.2013.157. Epub 2013 Aug 27. PMID: 23979220.

7. Johnston CS, Buller AJ. Vinegar and peanut products as complementary foods to reduce postprandial glycemia. J Am Diet Assoc. 2005 Dec;105(12):1939-42. doi: 10.1016/j.jada.2005.07.012. PMID: 16321601.

8. Liljeberg H, Björck I. Delayed gastric emptying rate may explain improved glycaemia in healthy subjects to a starchy meal with added vinegar. Eur J Clin Nutr. 1998 May;52(5):368-71. doi: 10.1038/sj.ejcn.1600572. PMID: 9630389.

9. Harpaz E, Tamir S, Weinstein A, Weinstein Y. The effect of caffeine on energy balance. J Basic Clin Physiol Pharmacol. 2017 Jan 1;28(1):1-10. doi: 10.1515/jbcpp-2016-0090. PMID: 27824614.

10. Kim, T., Shin, Y., Lee, J. et al. Effect of caffeine on the metabolic responses of lipolysis and activated sweat gland density in human during physical activity. Food Sci Biotechnol 19, 1077–1081 (2010). https://doi.org/10.1007/s10068-010-0151-6

11. Keijzers GB, De Galan BE, Tack CJ, Smits P. Caffeine can decrease insulin sensitivity in humans. Diabetes Care. 2002 Feb;25(2):364-9. doi: 10.2337/diacare.25.2.364. PMID: 11815511.

12. Anderson DE, Hickey MS. Effects of caffeine on the metabolic and catecholamine responses to exercise in 5 and 28 degrees C. Med Sci Sports Exerc. 1994 Apr;26(4):453-8. PMID: 8201901.

13. Doherty M, Smith PM. Effects of caffeine ingestion on rating of perceived exertion during and after exercise: a meta-analysis. Scand J Med Sci Sports. 2005 Apr;15(2):69-78. doi: 10.1111/j.1600-0838.2005.00445.x. PMID: 15773860.

14. Doherty M, Smith PM. Effects of caffeine ingestion on exercise testing: a meta-analysis. Int J Sport Nutr Exerc Metab. 2004 Dec;14(6):626-46. doi: 10.1123/ijsnem.14.6.626. PMID: 15657469.

15. Dulloo AG, Geissler CA, Horton T, Collins A, Miller DS. Normal caffeine consumption: influence on thermogenesis and daily energy expenditure in lean and postobese human volunteers. Am J Clin Nutr. 1989 Jan;49(1):44-50. doi: 10.1093/ajcn/49.1.44. PMID: 2912010.

16. Koot P, Deurenberg P. Comparison of changes in energy expenditure and body temperatures after caffeine consumption. Ann Nutr Metab. 1995;39(3):135-42. doi: 10.1159/000177854. PMID: 7486839.

17. Acheson KJ, Gremaud G, Meirim I, Montigon F, Krebs Y, Fay LB, Gay LJ, Schneiter P, Schindler C, Tappy L. Metabolic effects of caffeine in humans: lipid oxidation or futile cycling? Am J Clin Nutr. 2004 Jan;79(1):40-6. doi: 10.1093/ajcn/79.1.40. PMID: 14684395.

18. Kim HS, Quon MJ, Kim JA. New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate. Redox Biol. 2014 Jan 10;2:187-95. doi: 10.1016/j.redox.2013.12.022. PMID: 24494192; PMCID: PMC3909779.

19. Dulloo AG, Seydoux J, Girardier L, Chantre P, Vandermander J. Green tea and thermogenesis: interactions between catechin-polyphenols, caffeine and sympathetic activity. Int J Obes Relat Metab Disord. 2000 Feb;24(2):252-8. doi: 10.1038/sj.ijo.0801101. PMID: 10702779.

20. Shixian Q, VanCrey B, Shi J, Kakuda Y, Jiang Y. Green tea extract thermogenesis-induced weight loss by epigallocatechin gallate inhibition of catechol-O-methyltransferase. J Med Food. 2006 Winter;9(4):451-8. doi: 10.1089/jmf.2006.9.451. PMID: 17201629.

21. Rains TM, Agarwal S, Maki KC. Antiobesity effects of green tea catechins: a mechanistic review. J Nutr Biochem. 2011 Jan;22(1):1-7. doi: 10.1016/j.jnutbio.2010.06.006. Epub 2010 Nov 5. PMID: 21115335.

22. Hursel R, Viechtbauer W, Dulloo AG, Tremblay A, Tappy L, Rumpler W, Westerterp-Plantenga MS. The effects of catechin rich teas and caffeine on energy expenditure and fat oxidation: a meta-analysis. Obes Rev. 2011 Jul;12(7):e573-81. doi: 10.1111/j.1467-789X.2011.00862.x. Epub 2011 Mar 2. PMID: 21366839.

23. Hodgson AB, Randell RK, Jeukendrup AE. The effect of green tea extract on fat oxidation at rest and during exercise: evidence of efficacy and proposed mechanisms. Adv Nutr. 2013 Mar 1;4(2):129-40. doi: 10.3945/an.112.003269. PMID: 23493529; PMCID: PMC3649093.

24. Coutinho SR, Rehfeld JF, Holst JJ, Kulseng B, Martins C. Impact of weight loss achieved through a multidisciplinary intervention on appetite in patients with severe obesity. Am J Physiol Endocrinol Metab. 2018 Jul 1;315(1):E91-E98. doi: 10.1152/ajpendo.00322.2017. Epub 2018 Jan 23. PMID: 29360396.

25. Martins C, Kulseng B, King NA, Holst JJ, Blundell JE. The effects of exercise-induced weight loss on appetite-related peptides and motivation to eat. J Clin Endocrinol Metab. 2010 Apr;95(4):1609-16. doi: 10.1210/jc.2009-2082. Epub 2010 Feb 11. PMID: 20150577.

26. King NA, Caudwell PP, Hopkins M, Stubbs JR, Naslund E, Blundell JE. Dual-process action of exercise on appetite control: increase in orexigenic drive but improvement in meal-induced satiety. Am J Clin Nutr. 2009 Oct;90(4):921-7. doi: 10.3945/ajcn.2009.27706. Epub 2009 Aug 12. PMID: 19675105.

27. Heisler LK, Jobst EE, Sutton GM, Zhou L, Borok E, Thornton-Jones Z, Liu HY, Zigman JM, Balthasar N, Kishi T, Lee CE, Aschkenasi CJ, Zhang CY, Yu J, Boss O, Mountjoy KG, Clifton PG, Lowell BB, Friedman JM, Horvath T, Butler AA, Elmquist JK, Cowley MA. Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron. 2006 Jul 20;51(2):239-49. doi: 10.1016/j.neuron.2006.06.004. PMID: 16846858.

28. Cangiano C, Laviano A, Del Ben M, Preziosa I, Angelico F, Cascino A, Rossi-Fanelli F. Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients. Int J Obes Relat Metab Disord. 1998 Jul;22(7):648-54. doi: 10.1038/sj.ijo.0800642. PMID: 9705024.

29. Vashadze ShV. [Insomnia, serotonin and depression]. Georgian Med News. 2007 Sep;(150):22-4. Russian. PMID: 17984558.

30. Wurtman RJ, Wurtman JJ. Brain serotonin, carbohydrate-craving, obesity and depression. Obes Res. 1995 Nov;3 Suppl 4:477S-480S. doi: 10.1002/j.1550-8528.1995.tb00215.x. PMID: 8697046.

31. JOHN F. MUELLER, M.D., JAMES M. IACONO, PH.D., Effect of Desoxypyridoxine-Induced Vitamin B6 Deficiency on Polyunsaturated Fatty Acid Metabolism in Human Beings, The American Journal of Clinical Nutrition, Volume 12, Issue 5, May 1963, Pages 358–367, https://doi.org/10.1093/ajcn/12.5.358

32. National Institutes of Health: Office of Dietary Supplements. Vitamin B6.

33. Maeda H, Hosokawa M, Sashima T, Funayama K, Miyashita K. Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues. Biochem Biophys Res Commun. 2005 Jul 1;332(2):392-7. doi: 10.1016/j.bbrc.2005.05.002. PMID: 15896707.

34. Maeda H, Hosokawa M, Sashima T, Takahashi N, Kawada T, Miyashita K. Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells. Int J Mol Med. 2006 Jul;18(1):147-52. PMID: 16786166.

35. Gammone MA, D'Orazio N. Anti-obesity activity of the marine carotenoid fucoxanthin. Mar Drugs. 2015 Apr 13;13(4):2196-214. doi: 10.3390/md13042196. PMID: 25871295; PMCID: PMC4413207.

36. Abidov M, Ramazanov Z, Seifulla R, Grachev S. The effects of Xanthigen in the weight management of obese premenopausal women with non-alcoholic fatty liver disease and normal liver fat. Diabetes Obes Metab. 2010 Jan;12(1):72-81. doi: 10.1111/j.1463-1326.2009.01132.x. Epub 2009 Oct 13. PMID: 19840063.

* These statements have not been evaluated by the FDA. Our products are not intended to diagnose, treat, cure, or prevent any disease.

Warning Prop 65 for California Residents: This product may expose you to chemicals which are known to the State of California to cause cancer and birth defects or other reproductive harm. For more information, go to https://www.p65warnings.ca.gov/.

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