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MPO Muscle Performance Optimizer

$74.99 or $74.99 $67.49 / month

A stimulant-free true performance enhancer that improves the way your muscles work. The synergy of 5 natural active ingredients will make you feel dramatically stronger and more unstoppable than ever with increased power, endurance, and recovery.*

Experience a real athletic difference, not the jittery, over-stimulated feel of standard pre-workouts.*

  • trials show MPO will increase your muscle power & strength*
  • increase your muscle endurance in training and competition*
  • natural mTOR & growth stimulators increase muscle growth*
  • improve your recovery by decreasing muscle soreness (DOMS) & muscle damage (EIMD)*

Currently shipping MPO with our new and improved Blue Raspberry flavor.

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Free Shipping & 100% Satisfaction Guarantee

MPO Build Size & Strength

  1. increase your strength:
    the synergy of 5 natural active ingredients will make you push more weight
  2. improve workouts:
    our unique formula will increase available muscle energy/endurance for increased sets, reps and time under tension
  3. increase muscle growth:
    the natural anabolic mTOR and growth stimulators provide powerful clinical results that surpass testosterone
  4. improve recovery:
    anti-catabolic formula decreases delayed onset muscle soreness (DOMS) and exercise induced muscle damage (EIMD)

The Bottom Line

  • MPO is going to make you stronger.
  • MPO is going to improve your workouts.
  • MPO, if taken daily with proper diet, is going to make you bigger.
  • MPO actually improves the way your muscles work unlike stimulant/junk filled pre-workouts.
  • We do not call MPO a pre-workout because it is stimulant-free. That said, take MPO before every workout and you will actually perform better.
  • MPO works on your first dose - no loading necessary.
  • You put the time in, now it's time to get the results you deserve.
5 NaturalIngredients

What's in MPO?

MPO combines 5 natural active ingredients at clinical doses. Each ingredient improves the way your muscles work and will help build size and strength each and every time you take MPO.

See Ingredients
  • Phosphatidic Acid (PA)

    Phosphatidic Acid is a natural, plant derived lipid that stimulates muscle growth by at least two biochemical pathways:

    1. PA activates the enzyme p70-S6. This enzyme is stimulated by muscle damage; what typically occurs with weight lifting.(1)
    2. PA is a regulator of mTOR activation, the critical step in turning on muscle protein synthesis and growing new muscle cells.(2)

    As such, PA increases muscle growth and strength in athletes performing intense exercise.

    The Studies:

    One clinical study demonstrated PA supplementation with resistance training produced an increase in lean body mass by 2.4kg, an increase in cross-sectional size by 1cm and increase in leg press strength by 51.9kg in 8 weeks.(1)

    Other studies demonstrated an increase in bench and leg press strength, as well as increased squat by 8-12%.(2,3)

  • HMB (beta-Hydroxy-beta-methylbutyrate)

    HMB will increase muscle growth, decreases muscle breakdown, and help breakdown fat.

    It is naturally created in the muscle by the metabolism of the amino acid leucine, and it works works through a series of chemical reactions in the muscle cell that turns on growth genes within the cell.

    These chemical reactions then stimulate mTOR and turn on muscle protein synthesis.

    The Studies:

    One clinical study demonstrated that HMB supplementation increased bench press 55% and lower body strength over 100% when compared to placebo.

    Also, in an 8 week study, HMB increased 1-RM 14% and increased lean mass.(6,7,8,9,10,11)

  • HICA (Alpha-Hydroxy-Isocaproic Acid)

    HICA, otherwise known as leucic acid, decreases muscle breakdown after intense exercise, and decreases delayed onset muscle soreness (DOMS).

    Less muscle breakdown means greater gains in the long run, and less DOMS allows you to train harder and more effectively on subsequent days.

    HICA, like a HMB, is a normal metabolite of leucine, but it is formed by a different pathway.

    The Studies:

    Clinical studies showed that HICA supplementation with soccer players and wrestlers increased lean muscle mass, while the placebo group actually lost muscle. HICA supplementation also decreased DOMS compared to the placebo groups.(12,13)

  • Beta-Alanine

    Beta-Alanine helps you train harder and longer.

    It is an amino acid that is converted in the muscle to carnosine. This conversion helps buffer acid that builds up in the muscle with intense exercise. The acid buildup is known as lactic acid, and the lactic acid burn. Lactic acid buildup is a cause for muscle fatigue.(16,17)

    Beta-Alanine also appears to decrease the formation of free radicals that appear with strenuous exercise, and that produce muscle fatigue. (18,19)

    That said, beta-alanine increases high intensity exercise performance and augments the improvements that occur with training. It increases the anaerobic capacity seen with weight lifting, and increases the training volume. The greater the volume and time seen under tension, the greater the results.(14,15)

  • Creatine Monohydrate

    Long known as a muscle builder, creatine monohydrate works by increasing the energy in the muscle allowing you to lift more and work harder. The more work the muscle performs, the greater it will grow. This results in greater strength, greater power and ultimately greater muscle mass.(20)

    The Studies:

    In numerous studies over 25 years Creatine has been shown compared to placebo to increase weight lifting performance: 1-RM 8%, number of reps 14% and bench press 16-43%.(21)

    Creatine increases the size of type I, type IIA and type IIX muscle fibers and leads to greater muscle mass. Creatine works by increasing the energy systems in the muscle cell and increasing growth factors.(22,23)

Informed-Choice Certified

Learn More

This Product is Informed-Choice for Sport Certified.

Brain is batch tested by LGC’s world class sports anti-doping labs. The World Anti-Doping Agency and the United States Anti-Doping Agency have identified and banned over 220 performance enhancing drugs. Athletes that compete on the world stage such as Olympians, Professionals and Collegians are prohibited from using any products that may contain these banned substances.

LGC tests and certifies under their Informed Choice and Informed Sport programs that products wearing the Informed Sport and/or the Informed Choice logo(s) are banned substance tested.

In addition, to ensure your safety as per FDA and cGMP standards, Brain is further tested for heavy metals, yeast and bacterial counts.

We are proud to take the extra step and be part of the Informed Sport program so that athletes at the highest level can gain the unique advantage of our supplements with peace of mind.

Ingredients & Usage

Direction & Warnings


MPO dosing is based on athlete lean body weight.


  • 100-130 lbs - 1/2 scoop
  • 131-190 lbs - 1 scoop
  • 191-240 lbs - 1.5 scoops
  • 241 lbs and above - 2 scoops

Drink 30 minutes prior to exercise. MPO is not meant to be sipped. Drink completely at one time. To gain muscle, we recommend taking MPO daily, even on days off. It's not necessary to cycle on and off MPO


This product is only intended for healthy adults, 18 years of age or older. Do not use if pregnant or nursing. Consult with a physician before taking this or any dietary supplement product, especially if you are taking medication or have a medical condition. Use only as directed. Store in a cool, dry place. Keep out of reach of children.

Warning California's Proposition 65

Warning Prop 65

For California Residents

This product may expose you to chemicals which are known to the State of California to cause cancer and birth defects or other reproductive harm. For more information, go to https://www.p65warnings.ca.gov/.

MPO supplement facts

Your Top Questions, Answered

  • What is MPO?

    MPO is designed and guaranteed to build strength, power and size (with proper diet). MPO is the only product on the market that combines 5 ergogenic (high intensity performance aid) ingredients at optimal doses to actually improve the way your muscles work. Also, MPO is stimulant-free so you don't feel the jitters from normal pre-workouts.

  • What does MPO do?

    MPO increases strength, power and muscle endurance with each and every dose (that is why we guarantee satisfaction). You can expect to see increased reps, increased maximum loads and increased sets during training sessions.

    Additionally, explosive legs-based athletes (ice hockey, sprinters, some football positions) experience increased ‘leg jump’ and faster recovery.

  • Is MPO a preworkout?

    Yes and no.

    Always take MPO before a workout or athletic event. That said, it contains no stimulants like traditional pre-workouts so you won't be all hopped up and jittery.

  • Should I take MPO daily or only on days I exercise?

    If you are looking to increase mass, then take MPO daily.

    If you are an athlete that tends to lose mass during the course of your season, taking MPO daily will help minimize losses.

    If you are an older individual who is experiencing muscle loss with aging, take MPO daily to minimize muscle loss.

    If you are just looking to improve strength and power during workouts and athletic events, take MPO on those days.

  • Can MPO be mixed with my regular preworkout?

    Absolutely, you can stack MPO with your regular stim type preworkout. Our Brain product is an excellent choice if you are looking to improve focus and boost energy.

  • Can I stack MPO with any other Dioxyme products?

    We love to stack MPO with our BCAA's prior to workouts.

    By the way, sports science nutrition timing studies show that BCAA supplementation prior to workout is superior to whey protein prior to workout for muscle gains. So MPO plus BCAA's is the perfect combination.

    To take it one step further, you can also stack it with our Brain product for increased focus and energy. You can find all 3 products together in our Performance Stack.

  • What are the brown flecks in MPO?

    The brown flecks in the MPO are actually the ingredient Phosphatidic Acid. These flecks are completely safe (we've had them 3rd party tested), and they are the most potent form of Phosphatidic Acid on the market today.

  • Is MPO Vegan?

    MPO is vegan compliant and contains no animal based products.

  • Is MPO produced in cGMP facility?

    MPO is produced in a GMP (Good Manufacturing Practice) state of the art facility. This is done to ensure our quality and your safety.

    Moreover, our manufacturing facility is independently inspected and certified by NSF International to be a GMP facility. This means our facility follows the strictest standards in the manufacturing business.

  • Is MPO tested for banned substances?

    Yes, MPO is certified by Informed Choice for Sport who tests for over 220 performance enhancing drugs as identified by the World Anti-Doping Agency and the United States Anti-Doping Agency. Click here to learn about the Informed Choice process.

Real Reviews

Customer Reviews

Based on 86 reviews

Definitely satisfied !

Love it!

I love this product! I definitely noticed an increased strength and stamina immediately after taking it. Tastes great too!

Great Product

Definitely does the job and is a superior pre workout

MPO Best product on the market 💪

I was surprised how fast was the delivery 📦.


Just hadn't had long enough to see any results

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.


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