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muscle performance optimizer


muscle performance optimizer

Athleticism, power, strength, speed, endurance, and recovery are the result of 1000’s of chemical reactions in the muscles and nerves. MPO works at the biochemical level to increase force production, power, and endurance, and to help you rebuild post-exercise. Each time you take MPO, you’ll see noticeable improvements in game performance and training.*

When every second and every inch is the difference between winning and losing, take MPO.

  • Take prior to training & competition to maximize athletic performance.*
  • Take daily for improved muscle growth and recovery.*
  • Ideal for athletes across all spectrums:
  • Power: Olympic and Powerlifting
  • Speed & Power: Football, Rugby, MMA, Hockey, WODs
  • Speed & Endurance: Soccer, Tennis, Lacrosse, Swimming
  • Endurance: Running, Biking, Swimming

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muscle performance optimizer

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is mpo right for me?

Athleticism is defined by Webster as the combination of qualities that are characteristic of an athlete. In our opinion, these physical qualities include strength, power, aerobic & anaerobic endurance, your ability to recover, and flexibility. Other than the last one, MPO will improve every characteristic of your physical athletic ability.*

studied in pro athletes

Here’s some data: In a study of professional and D1 hockey players during a 13 week summer combine, athletes using MPO demonstrated an 11-18% increase in average power production, up to an 18.9% increase in peak power, and a 4.5% increase in anaerobic endurance. As is typically seen during intense combine training, the athletes not using MPO saw either no improvement, or declines in these metrics.

for pure strength

MPO increases the amount of ATP (fuel) in the muscle, decreases the accumulation of lactic acid, and inhibits neural fatigue. MPO also has multiple mTOR, IGF-1, GH, and satellite cell stimulators that increase muscle growth, as well as improve repair and recovery. These factors combine to improve your strength, to allow you to increase your set weight, reps, and time under tension, and to shorten your rest phase. You can expect to set new PR’s more frequently, and if you use MPO daily with proper nutrition, you can expect greater increases in muscle mass than you would without MPO.

when peak power meets speed

High intensity sports call for explosive bouts of maximal power, sustained focus, and all out speed. Football, rugby, sprinting, metabolic conditioning, WOD’s, and MMA all come to mind. Athletes in these areas of expertise require repetitive power and speed movements used with skill and accuracy. MPO increases your power production, maintains your speed and agility, and provides resistance to fatigue. This ensures peak performance and focus from start to finish.

speed, endurance, & consistency

Some sports, such as basketball, soccer, hockey, tennis, and lacrosse call for the unique combination of speed and endurance; of fast twitch and slow twitch muscle fibers. Athletes in these sports will see improvements in both physical qualities while using MPO. Since MPO inhibits muscle breakdown, neural fatigue, and the buildup of lactic acid, athletes will also experience quicker recovery between sprints, and sustained mental focus. Impressively, athletes will also maintain weight and avoid being worn down over the course of a long season while regularly using MPO. This equals greater consistency day in and day out, which is key to athletic success.

going the distance

For some, a finely tuned cardiovascular system, aerobic muscle fibers, and a strong mind are the tools of the trade. Long distance runners, cyclists, swimmers, hikers, and climbers fit into this category. MPO works unlike any other supplement for these endurance athletes. It increases VO2 max. It increases muscle ATP (the fuel needed for muscles to fire consistently during long athletic events). It also inhibits lactic acid build up. Higher lactic acid levels prevent glucose from being converted into ATP. Further, MPO prevents fatigue in the neuromuscular and central nervous systems. With less fatigue, your mind can stay sharp and focused. Lastly, it decreases muscle breakdown for improved recovery.

recovery is paramount

For all athletes, recovery is the key to success and consistency. MPO decreases muscle breakdown resulting from the micro-injuries that occur with exercise. This enables athletes to recover faster and minimizes DOMS (delayed onset muscle soreness), enabling you to maintain more muscle, repair muscle faster, and perform better day to day following intense athletic work. Often, it is not that exercise that is indicative of consistency and improved future performance, but the physiologic changes that happen during the recovery phase.

A Word From The Doctor

Why did you formulate this?

“The studies say it all. The right supplements at the right dose will produce measurable benefits that you can’t get from food alone. With that said, I never saw a measurable difference in my training, or my son’s training from anything on the market. The products were underdosed, were missing key ingredients, or had misleading labels. So, I took 5 proven nutraceuticals at clinical doses and combined them to create our flagship product MPO. The results exceeded expectations, and the synergy of the ingredients became greater than the results of the individual parts. MPO has enabled me to set multiple PR’s in my late 50’s, and produces quantifiable results in all the professional athletes we work with.”

Dr. Marc Schneider from Dioxyme



HMB is a naturally occurring substance and a metabolite of leucine. Some of the leucine that comes in through your daily diet is ultimately converted by the body into HMB. This amount however, is quite minuscule. As such, we need to supplement with HMB to realize its full potential.

The main benefits of HMB are promoting muscle growth and muscle strength, and preventing muscle breakdown.

To add size and strength, HMB stimulates muscle protein synthesis, the main mechanism that causes your muscles to grow. The higher your levels of MPS, the greater your muscle-building potential. Specifically, HMB has been shown to increase MPS through the activation of the mTOR signaling pathway, which helps coordinate the delivery of fresh nutrients like amino acids and oxygen to your muscles.

To highlight its effectiveness, one study compared the effects of HMB to placebo. After 12 weeks of supplementation, researchers found significantly greater increases in lean muscle mass in participants who ingested HMB vs placebo (7.4 kg vs 2.1 kg respectively). The participants consuming HMB also added 55 more kgs to their squat, bench, and deadlift totals in comparison to subjects who received only a placebo.

To prevent muscle breakdown, HMB prevents the process known as muscle protein breakdown (MPB). In simple terms, less MPB ultimately equates to less recovery time. If an intense workout doesn’t do as much damage to your muscle tissues, it won’t take your body as much time to make repairs. Specifically, HMB alters muscle metabolism, and is shown to decrease the body’s production of enzymes like lactate dehydrogenase, which play a primary role in triggering MPB.

Phosphatidic Acid (PA) (Mediator™ PA)


Phosphatidic acid (PA) is a biomolecule produced naturally within your body. It plays an important part in cell signaling, the process of communication that takes place between your body’s cells in order to coordinate and regulate their actions.

Specifically, phosphatidic acid helps to promote mTOR signaling, which once activated, helps promote muscle protein synthesis and cellular growth. The mTOR signaling pathway actively senses and reacts to environmental stimuli, helping to coordinate the transportation of proteins (along with oxygen and other biochemicals) to muscle cells in need of repair.

To date, most studies have found that compared to resistance training alone, PA supplementation led to significantly greater gains in size and strength.

Over the course of one 8-week resistance training study, participants given phosphatidic acid gained on average 2.4 more kilograms of lean body mass than those given placebo. In another 8-week trial, those given phosphatidic acid added on average almost 20 more kilograms to their 1 rep max on the leg press than those given placebo, +52kg vs +32.5kg respectively.



Beta-alanine is a naturally occurring non-essential amino acid that produces carnosine, a peptide that acts as an inhibitor to the chemical reactions that occur in your muscles during physically demanding exercise.

As such, the main benefits of beta-alanine are its ability to increase anaerobic endurance, and to help build strength.

When you work out, your muscles are actively taking in glucose, which is your body’s primary fuel source. When glucose is burnt up, it leaves behind lactic acid. As the acidity builds up in your muscles, their capacity to take in more glucose becomes diminished. Without the glucose needed for energy, your muscles become exhausted. That… and you “feel the burn”.

The carnosine that beta-alanine creates though, helps to reduce the buildup of lactic acid, which allows additional glucose to enter into your muscles during high-intensity exercise. In clinical trials, sprinters who consumed beta-alanine were able to sustain greater power outputs for longer durations of time compared to sprinters who did not.

While beta-alanine is most effective for high-intensity exercise, that doesn’t mean that it has no benefit for endurance athletes. In fact, in one study involving elite cyclists, researchers found that supplementing with beta-alanine significantly improves cyclists’ sprinting performances at the end of long bouts of endurance-based exercise.

Finally, studies also show that beta-alanine increases strength. In one such study, researchers found that after 5 weeks of training, those who supplemented with beta-alanine saw significantly greater increases in their power outputs compared to the placebo group.



HICA is another naturally occurring, bioactive, organic compound found in the body that, when provided as a supplement, significantly enhances muscular function and development.

Like HMB, your body naturally produces HICA during the metabolism of leucine. With that said, the muscles and connective tissues use and metabolize leucine via two different biochemical pathways, and of course HMB uses one, and HICA uses the other (the KIC pathway to be specific).

Also like HMB, scientists consider HICA to be anabolic since it enhances muscle protein synthesis. It may do this via a variety of means, but studies indicate that HICA is anabolic because it supports mTOR activation.

HICA has also been shown to have anti-catabolic properties as well, meaning that it helps to prevent the breakdown of muscle proteins found within muscle tissues. As you exercise intensely, your muscles undergo micro-trauma that causes the muscle cells to break down. We all feel the effects of this micro-trauma 24-48 hours after intense exercise in the form of delayed onset muscle soreness (DOMS). HICA significantly decreases this breakdown or catabolism. The result of this is less DOMS, and more lean muscle to build upon.

In recent athlete studies, scientists noted that the athletes who took HICA over a 6-week period gained 2 pounds and noted significantly less muscle soreness. What is even more interesting about the trials though, is that the placebo group actually lost lean muscle mass. This makes HICA a very important supplement for any athlete performing high-intensity exercise.

Creatine Monohydrate


Creatine monohydrate is one of the original and most extensively studied weightlifting supplements on the market. In fact, there have been thousands of studies spanning multiple decades that show creatine is a top supplement for improving exercise performance.

Creatine is a naturally occurring compound that’s found primarily in your muscle cells. The main benefits of creatine are increasing muscle energy, muscle size, and muscle strength.

To provide your muscles with energy, creatine increases the amount of phosphocreatine within your muscle cells. Phosphocreatine is used by your muscles during high-intensity activity to produce ATP, which is an energy source, and also the driving factor behind numerous processes within the human body such as muscle contractions.

Impressively, studies consistently demonstrate that creatine monohydrate can increase phosphocreatine concentrations in the muscles by as much as 40%. This means that there is more available energy in your muscles when exercising, which leads to improvements in both anaerobic and aerobic endurance.

To increase muscle growth, creatine increases intramuscular concentrations of IGF, and increases the number of satellite cells and myonuclei in your muscle fibers. Studies show that both of these factors help add lean muscle mass. The combination of these factors, coupled with an increase in available energy, leads to improvements in muscle strength as well.

Amazingly, both short and long-term studies show creatine monohydrate leads to at least 5-15% greater gains in strength and performance. One study even demonstrated an increase in 1RM (one rep max) of 8%, and an increased bench press of 16-43% when compared to placebo.

suggested use


Drink MPO 30 minutes prior to exercise. MPO is not meant to be sipped. Drink completely at one time. To gain muscle we recommend taking MPO daily, even on days off. It is not necessary to cycle on and off MPO.


It is the first of its kind, physician formulated, athletic performance enhancer. Experience real increases in your muscle strength, power, endurance, and recovery.

It is the first of its kind, physician formulated, athletic performance enhancer. Experience real increases in your muscle strength, power, endurance, and recovery.

Though we recommend taking MPO before all workouts and competitions, MPO is not a pre-workout in the traditional sense. MPO does not contain any stimulants like traditional pre-workouts. As such, you will not develop stim fatigue like you do on standard pre-workouts. Instead, MPO actually improves the way your muscles function to improve workouts and athletic performance.

Though we recommend taking MPO before all workouts and competitions, MPO is not a pre-workout in the traditional sense. MPO does not contain any stimulants like traditional pre-workouts. As such, you will not develop stim fatigue like you do on standard pre-workouts. Instead, MPO actually improves the way your muscles function to improve workouts and athletic performance.

If you are looking to build muscle or prevent muscle loss (such as when you are recovering from injury or because of aging), we recommend taking MPO every day, including days off from exercise.

If you are looking to build muscle or prevent muscle loss (such as when you are recovering from injury or because of aging), we recommend taking MPO every day, including days off from exercise.

If you are looking to add stimulants to your pre-workout, then yes, you can stack MPO with a traditional pre-workout.  But a better option would be to use MPO with BRAIN.

If you are looking to add stimulants to your pre-workout, then yes, you can stack MPO with a traditional pre-workout.  But a better option would be to use MPO with BRAIN.

Yes it is.

Yes it is.

MPO will kick in in 30 minutes.**

If you are using this prior to training, we suggest you take MPO at least 30 minutes before hitting the gym.

If you are using this for athletic competition, most of our professional athletes take MPO 30 minutes before the competition starts.

MPO will kick in in 30 minutes.**

If you are using this prior to training, we suggest you take MPO at least 30 minutes before hitting the gym.

If you are using this for athletic competition, most of our professional athletes take MPO 30 minutes before the competition starts.

Yes. MPO is produced in a GMP (Good Manufacturing Practice), state of the art facility to ensure quality and your safety.

Yes. MPO is produced in a GMP (Good Manufacturing Practice), state of the art facility to ensure quality and your safety.

Customer Reviews

Based on 118 reviews
Calvin Jamison
MPO, pre workout or super serum?

First thing, it’s definitely not a tasty beverage, it has a medicine like taste. Best to just chug it. That being said, HOLY CRAP they freeze dried Superman and ground him into a powder. First time I used it, I felt like my muscles were numb to the torture I was inflicting on them. Every workout I’ve had since using it has been really good. Great product, would highly recommend.


The absolute best preworkout on the market.
No jitters...just pure, clean fuel

Great Product

I gained 20 pounds in my squat in less than a month after taking this

Cristian B Popadiuc

Love this pre workout. My go to. It has all the correct amount of ingredients compared to the other pre workouts. Just wished it was cheaper

Mark Howard
Mark's Review

I use to take MPO a couple years ago, when Mi nutrition use to sale it in Royal oak, MI. And I liked the results, I stopped buying it and then I was trying to find it. Then I looked online and i found it. Since I got back into it, Time to get back to my gains and quick recovery 💪


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* These statements have not been evaluated by the FDA. Our products are not intended to diagnose, treat, cure, or prevent any disease.

** Most users feel a noticeable effect within 30-45 minutes. Results may vary.

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